【结 构 式】 |
【药物名称】R-61837 【化学名称】3-Methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine 【CA登记号】100241-46-1 【 分 子 式 】C16H20N4O 【 分 子 量 】284.364 |
【开发单位】Janssen (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antiviral Drugs |
合成路线1
N-Alkylation of 1-(3-methylphenyl)piperazine with 3,6-dichloropyridazine in dimethylformamide as a solvent and in the presence of sodium carbonate afforded 3-chloro-6-[4-(3-methylphenyl-1-piperazinyl]pyridazine. The reactive chlorine atom in this intermediate was replaced by a methoxy group, by refluxing the compound in methanol containing an excess of sodium methoxide. After addition of water to the cooled reaction mixture the product crystallized. Recrystallization from 2-propanol produced pure 3-methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine.
【1】 Andries, K.; Stokbroekx, R.; R 61837. Drugs Fut 1990, 15, 3, 237. |