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【结 构 式】

【药物名称】R-61837

【化学名称】3-Methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine

【CA登记号】100241-46-1

【 分 子 式 】C16H20N4O

【 分 子 量 】284.364

【开发单位】Janssen (Originator)

【药理作用】ANTIINFECTIVE THERAPY, Antiviral Drugs

合成路线1

N-Alkylation of 1-(3-methylphenyl)piperazine with 3,6-dichloropyridazine in dimethylformamide as a solvent and in the presence of sodium carbonate afforded 3-chloro-6-[4-(3-methylphenyl-1-piperazinyl]pyridazine. The reactive chlorine atom in this intermediate was replaced by a methoxy group, by refluxing the compound in methanol containing an excess of sodium methoxide. After addition of water to the cooled reaction mixture the product crystallized. Recrystallization from 2-propanol produced pure 3-methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine.

1 Andries, K.; Stokbroekx, R.; R 61837. Drugs Fut 1990, 15, 3, 237.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11292 3,6-Dichloropyridazine 141-30-0 C4H2Cl2N2 详情 详情
(II) 11293 1-(3-Methylphenyl)piperazine 41186-03-2 C11H16N2 详情 详情
(III) 11294 3-Chloro-6-[4-(3-methylphenyl)piperazino]pyridazine C15H17ClN4 详情 详情
Extended Information