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【结 构 式】 
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【分子编号】10490 【品名】(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetanone 【CA登记号】 |
【 分 子 式 】C22H27NO3Si 【 分 子 量 】381.54682 【元素组成】C 69.26% H 7.13% N 3.67% O 12.58% Si 7.36% |
合成路线1
该中间体在本合成路线中的序号：(XVIII)The synthesis of tritium-labeled taxol [13-3H]-taxol (b) has been described: The oxidation of baccatin III (I) with MnO2 in chloroform gives 13-oxobaccatin III (XV), which is silylated with chlorotriethylsilane in pyridine yielding 13-oxo-7-O-(triethylsilyl)baccatin III (XVI). The reduction of (XVI) with tritiated borane (prepared from tritiated sodium borohydride and BF3) in THF affords [13-3H]-7-O-(triethylsilyl)baccatin III (XVII), which is condensed with (3S-cis)-1-benzoyl-4-phenyl-3-(trimethylsilyloxy)azetidin-2-one (XVIII) by means of butyllithium in THF to give [13-3H]-2',7-bis-O-(triethylsilyl)taxol (XIX). Finally, this compound is deprotected with 48% HF and pyridine in THF.
| 【1】 Taylor, G.F.; Thornton, S.S.; Tallent, C.R.; Kepler, J.A.; Synthesis of [3''-3H]taxol and [13-3H]taxol. J Label Compd Radiopharm 1993, 33, 6, 501. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10447 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-1,9,15-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C31H38O11 | 详情 | 详情 | |
| (XV) | 10487 | (1S,2S,3R,4S,7R,9S,10S,12R)-4,12-bis(acetoxy)-1,9-dihydroxy-10,14,17,17-tetramethyl-11,15-dioxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C31H36O11 | 详情 | 详情 | |
| (XVI) | 10488 | (1S,2S,3R,4S,7R,9S,10S,12R)-4,12-bis(acetoxy)-1-hydroxy-10,14,17,17-tetramethyl-11,15-dioxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C37H50O11Si | 详情 | 详情 | |
| (XVII) | 10489 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C31H37O11T | 详情 | 详情 | |
| (XVII) | 44661 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C37H52O11Si | 详情 | 详情 | |
| (XVIII) | 10490 | (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetanone | C22H27NO3Si | 详情 | 详情 | |
| (XIX) | 10491 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-([(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl]oxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C59H79NO14Si2 | 详情 | 详情 | |
| (XIX) | 44662 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-([(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl]oxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl | C59H79NO14Si2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XXIII)Compound (XV) is selectively acetylated with acetic anhydride and DMAP to the diol (XVI). The replacement of the benzyl protecting group by a triethylsilyl (TES) group in (XVI) by debenzylation with H2 over Pd(OH)2/C followed by treatment with TESCl in pyridine and deacetylation with K2CO3 in methanol affords the silylated triol (XVII). The formation of the oxetane ring is carried out by treatment of (XVII) with trimethylsilyl chloride (TMSCl) and pyridine (silylation of the primary alcohol), subsequent reaction with Tf2O (activation of the secondary alcohol), and cyclization by acidic treatment with CSA to give compound (XVIII) with the oxetane ring and a tertiary OH group. The acetylation of (XVIII) with acetic anhydride and DMAP affords compound (XIX) with the tertiary acetoxy group. The reaction of (XIX) with phenyllithium gives the benzoyloxy derivative (XX), which is oxidized with pyridinium chlorochromate (PCC) to yield the diketone (XXI). The reduction of (XXI) with NaBH4 in methanol affords compound (XXII) with the appropriate secondary hydroxy group, which is acylated with Ojima's beta-lactam (XXIII) by means of sodium bis(trimethylsilyl)amide to give the silylated paclitaxel (XXIV). Finally, this compound is deprotected with HF/pyridine.
| 【1】 Yang, Z.; Liu, J.J.; Nicolaou, K.C.; et al.; Total synthesis of taxol. Nature 1994, 367, 6464, 630. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XV) | 10526 | (1S,5S,6R,7S,8S,10S,11S,13R)-7,8,10-trihydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3,12-dioxo-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate | C23H32O10 | 详情 | 详情 | |
| (XVI) | 10527 | (1S,5S,6R,7S,8S,10S,11S,13R)-7-[(acetoxy)methyl]-7,8,10-trihydroxy-11,15,18,18-tetramethyl-3,12-dioxo-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate | C25H34O11 | 详情 | 详情 | |
| (XVII) | 10528 | (1S,5S,6R,7S,8S,10S,11S,13R)-7,8-dihydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3,12-dioxo-10-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate | C29H46O10Si | 详情 | 详情 | |
| (XVIII) | 10529 | (1S,5S,6R,7S,10R,12S,13S,15R)-7-hydroxy-13,17,20,20-tetramethyl-3,14-dioxo-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate | C29H44O9Si | 详情 | 详情 | |
| (XIX) | 10530 | (1S,5S,6R,10R,12S,13S,15R)-15-(acetoxy)-13,17,20,20-tetramethyl-3,14-dioxo-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate | C31H46O10Si | 详情 | 详情 | |
| (XX) | 10531 | (1S,2S,3R,4S,7R,9S,10S,12R)-4,12-bis(acetoxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C37H52O10Si | 详情 | 详情 | |
| (XXI) | 10488 | (1S,2S,3R,4S,7R,9S,10S,12R)-4,12-bis(acetoxy)-1-hydroxy-10,14,17,17-tetramethyl-11,15-dioxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C37H50O11Si | 详情 | 详情 | |
| (XXII) | 10473 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C37H52O11Si | 详情 | 详情 | |
| (XXIII) | 10490 | (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetanone | C22H27NO3Si | 详情 | 详情 | |
| (XXIV) | 10535 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-([(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl]oxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | n/a | AB | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XXXVII)The secondary alcohol (XXXII) is treated with phenyllithium in THF (to open the cyclic carbonate and form the benzoyloxy group) and oxidized with tetrapropylammonium perruthenate (TPAP) to give the benzoyloxyketone (XXXIII). Enolization of ketone (XXXIII) with potassium tert-butoxide affords the potassium enolate (XXXIV), which is oxidized with phenylseleninic anhydride and acetylated with acetic anhydride in DMAP to give the alpha-acetoxyketone (XXXV). Further desilylation of (XXXV) with tris(diethylamino)sulfoxonium difluorotrimethylsiliconate (TASF) in THF yields the secondary alcohol (XXXVI), which is condensed with Ojima's beta-lactam (XXXVII) by means of lithium hexamethyldisilazane (LHMDS) in THF to afford protected paclitaxel (XXXVIII). Finally, this compound is deprotected first with HF in pyridine to eliminate the triethylsilyl (TES) group and then hydrogenated with H2 over Pd/C in ethanol to eliminate the BOM group.
| 【1】 Kim, H.-B.; Holton, R.A.; Somoza, C.; et al.; First total synthesis of taxol. 2. Completion of the C and D rings. J Am Chem Soc 1994, 116, 4, 1599. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXXII) | 10589 | (1S,5S,6R,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[[tert-butyl(dimethyl)silyl]oxy]-15-hydroxy-13,17,20,20-tetramethyl-3-oxo-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate | C37H54O9Si | 详情 | 详情 | |
| (XXXIII) | 10590 | (1S,2S,3R,4S,7R,9S,10R,15S)-4-(acetoxy)-9-[(benzyloxy)methyl]-15-[[tert-butyl(dimethyl)silyl]oxy]-1-hydroxy-10,14,17,17-tetramethyl-12-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C43H58O9Si | 详情 | 详情 | |
| (XXXIV) | 10591 | potassium (1S,2S,3R,4S,7R,9S,10S,15S)-4-(acetoxy)-2-(benzoyloxy)-9-[(benzyloxy)methyl]-15-[[tert-butyl(dimethyl)silyl]oxy]-1-hydroxy-10,14,17,17-tetramethyl-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadeca-11,13-dien-12-olate | C43H57KO9Si | 详情 | 详情 | |
| (XXXV) | 10592 | (1S,2S,3R,4S,7R,9S,10R,12R,15S)-4,12-bis(acetoxy)-9-[(benzyloxy)methyl]-15-[[tert-butyl(dimethyl)silyl]oxy]-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C45H60O11Si | 详情 | 详情 | |
| (XXXVI) | 10593 | (1S,2S,3R,4S,7R,9S,10R,12R,15S)-4,12-bis(acetoxy)-9-[(benzyloxy)methyl]-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C39H46O11 | 详情 | 详情 | |
| (XXXVII) | 10490 | (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetanone | C22H27NO3Si | 详情 | 详情 | |
| (XXXVIII) | 10595 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-[[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy]-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | 33069-62-4 | C47H51NO14 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(XX)The debenzylation of (XVI) by hydrogenation, and subsequent reaction with triphosgene afforded the cyclic carbonate (XVII), which was acetylated with acetic anhydride and treated with phenyllithium in THF to open the cyclic carbonate giving the benzoate (XVIII). Compound (XVIII) was submitted to a deprotection protection cycle, first with HF and pyridine followed by a treatment with Troc-Cl in the same solvent, providing intermediate (XIX). Finally, compound (XIX) was desilylated with TASF in THF, condensed with azetidinone (XX) and deprotected with Zn/acetic acid to provide taxol.
| 【1】 Morihira, K.; et al.; Enantioselective total synthesis of Taxol. J Am Chem Soc 1998, 120, 49, 12980. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVI) | 32003 | (1S,3S,5S,6R,7S,10R,12S,13S,15R,18S)-7-hydroxy-13,17,20,20-tetramethyl-14-oxo-3-phenyl-18-[(tributylsilyl)oxy]-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate | C47H76O9Si2 | 详情 | 详情 | |
| (XVII) | 32004 | (1S,5S,6R,7S,10R,12S,13S,15R,18S)-7-hydroxy-13,17,20,20-tetramethyl-3,14-dioxo-18-[(tributylsilyl)oxy]-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate | C41H70O10Si2 | 详情 | 详情 | |
| (XVIII) | 32005 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-15-[(tributylsilyl)oxy]-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C49H78O11Si2 | 详情 | 详情 | |
| (XIX) | 32006 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-15-[(tributylsilyl)oxy]-9-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C46H65Cl3O13Si | 详情 | 详情 | |
| (XX) | 10490 | (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetanone | C22H27NO3Si | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(XIII)A new synthesis of (3R,4S)-1-benzyl-4-phenyl-3-(triethylsilyloxy)azetidin-2-one (XIII), a precursor of the side chain of paclitaxel, has been described: The reaction of ethyl L-tartrate (I) with benzaldehyde and TsOH followed, by reduction with LiAlH4 and AlCl3 gives the monobenzylated tretraol (II), which is submitted to an oxidative cleavage of the alpha-diol bond with NaIO4 to yield the aldehyde (III). Reaction of (III) with benzylamine affords the imine (IV), which is submitted to a Grignard addition of phenylmagnesium bromide in ether providing a 1:9 mixture of aminoalcohols (VI) and (VII) separated by chromatography. Oxidation of the desired major isomer (VII) with CrO3/H2SO4 gives the corresponding acid (VIII), which is then esterified with TMS-Cl in refluxing methanol to the methyl ester (IX). Deprotection of compound (IX) by hydrogenolysis with reluxing HCO2H over Pd/C yields 3(S)-amino-2(R)-hydroxy-3-phenylpropionic acid methyl ester (X), which is silylated at the OH group of with TES-Cl and TEA in ether/THF to afford the silyl ether (XI). Cyclization of (XI) by means of LHMDS in THF provides the beta-lactam (XII), which is finally benzoylated with benzoyl chloride and TEA in the usual way.
| 【1】 Kim, H.-K.; Kim, S.-C.; Synthesis of new Taxol side chain precursor from L-tartaric ester. Bull Korean Chem Soc 2000, 21, 10, 1047. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16696 | Diethyl L-(+)-Tartrate; diethyl (2S,3S)-2,3-dihydroxybutanedioate | 87-91-2 | C8H14O6 | 详情 | 详情 |
| (II) | 43826 | (2S,3S)-3-(benzyloxy)-1,2,4-butanetriol | C11H16O4 | 详情 | 详情 | |
| (III) | 43827 | (2S)-2-(benzyloxy)-3-hydroxypropanal | C10H12O3 | 详情 | 详情 | |
| (IV) | 15147 | Benzylamine; Phenylmethanamine | 100-46-9 | C7H9N | 详情 | 详情 |
| (V) | 43828 | (2R)-3-(benzylimino)-2-(benzyloxy)-1-propanol | C17H19NO2 | 详情 | 详情 | |
| (VI) | 43829 | (2R,3R)-3-(benzylamino)-2-(benzyloxy)-3-phenyl-1-propanol | C23H25NO2 | 详情 | 详情 | |
| (VII) | 43830 | (2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenyl-1-propanol | C23H25NO2 | 详情 | 详情 | |
| (VIII) | 43831 | (2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropionic acid | C23H23NO3 | 详情 | 详情 | |
| (IX) | 43832 | methyl (2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropanoate | C24H25NO3 | 详情 | 详情 | |
| (X) | 43833 | methyl (2R,3S)-3-amino-2-hydroxy-3-phenylpropanoate | C10H13NO3 | 详情 | 详情 | |
| (XI) | 43834 | methyl (2R,3S)-3-amino-3-phenyl-2-[(triethylsilyl)oxy]propanoate | C16H27NO3Si | 详情 | 详情 | |
| (XII) | 10685 | (3R,4S)-4-Phenyl-3-[(triethylsilyl)oxy]-2-azetidinone | C15H23NO2Si | 详情 | 详情 | |
| (XIII) | 10490 | (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetanone | C22H27NO3Si | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(XLVIII)Condensation of (XLVII) with the chiral azetidinone (XLVIII) by means of LiHMDS in THF provides the protected paclitaxel precursor (LIX), which is finally deprotected with Zn in HOAc/water.
| 【1】 Kashima, H.; Kusama, H.; Hara, R.; Morihira, K.; Nakamura, N.; Kuwajima, I.; Kawahara, S.; Nishimori, T.; Enantioselective total synthesis of (-)-Taxol. J Am Chem Soc 2000, 122, 16, 3811. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XLVII) | 10448 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C34H39Cl3O13 | 详情 | 详情 | |
| (XLVIII) | 10490 | (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetanone | C22H27NO3Si | 详情 | 详情 | |
| (XLIX) | 43876 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-([(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl]oxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]h | C56H66Cl3NO16Si | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(V)The silyl-protected 4-deacetyl baccatin (I) was deprotonated with lithium bis(trimethylsilyl) amide and then condensed with methyl chloroformate to produce carbonate (II). Desilylation of (II) using HF in pyridine afforded triol (III), which was selectively resilylated at the 7-hydroxyl group to furnish (IV). Attachment of the C-13 side-chain of (IV) was achieved by treatment with lactam (V) and lithium bis(trimethylsilyl)amide, yielding ester (VI). Finally, the silyl protecting groups of (VI) were removed by treatment with HF in pyridine.
| 【1】 Long, B.H.; Chen, S.H.; Wei, J.-M.; et al.; Novel C-4 paclitaxel (Taxol) analogs: Potent antitumor agents. Bioorg Med Chem Lett 1995, 5, 22, 2741. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 41096 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-12-(acetoxy)-1-[(dimethylsilyl)oxy]-4-hydroxy-10,14,17,17-tetramethyl-11-oxo-9,15-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C43H70O10Si3 | 详情 | 详情 | |
| (II) | 41097 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-12-(acetoxy)-1-[(dimethylsilyl)oxy]-4-[(methoxycarbonyl)oxy]-10,14,17,17-tetramethyl-11-oxo-9,15-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C45H72O12Si3 | 详情 | 详情 | |
| (III) | 41098 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-12-(acetoxy)-1,9,15-trihydroxy-4-[(methoxycarbonyl)oxy]-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C31H38O12 | 详情 | 详情 | |
| (IV) | 41099 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-12-(acetoxy)-1,15-dihydroxy-4-[(methoxycarbonyl)oxy]-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C37H52O12Si | 详情 | 详情 | |
| (V) | 10490 | (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetanone | C22H27NO3Si | 详情 | 详情 | |
| (VI) | 41100 | C59H79NO15Si2 | 详情 | 详情 |