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【结 构 式】 
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【分子编号】16056 【品名】4-[4-[(4-chlorophenyl)(2-pyridinyl)methoxy]piperidino]butyric acid 【CA登记号】 |
【 分 子 式 】C21H25ClN2O3 【 分 子 量 】388.89388 【元素组成】C 64.86% H 6.48% Cl 9.12% N 7.2% O 12.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The reaction of 4-[1-(4-chlorophenyl)-1-(2-pyridyl)methoxy]piperidine (I) with ethyl 4-bromobutyrate (II) by means of K2CO3 in refluxing acetone gives the corresponding condensation product (III), which is then hydrolyzed with NaOH in ethanol/water yielding compound (IV).
| 【1】 Castaner, J.; Graul, A.; Betotastine besilate. Drugs Fut 1998, 23, 3, 256. |
| 【2】 Koda, A.; Kuroki, Y.; Fujiwara, H.; Takamura, S.; Yamano, K. (Ube Industries, Ltd.); Piperidine and piperazine derivs., process for preparing the same and pharmaceutical compsns. containing them. EP 0335586; JP 1989242574; JP 1990025465; JP 1993294929; US 4929618 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16053 | 2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]pyridine; (4-chlorophenyl)(2-pyridinyl)methyl 4-piperidinyl ether | C17H19ClN2O | 详情 | 详情 | |
| (II) | 11263 | ethyl 4-bromobutanoate; Ethyl 4-bromobutyrate | 2969-81-5 | C6H11BrO2 | 详情 | 详情 |
| (III) | 16055 | ethyl 4-[4-[(4-chlorophenyl)(2-pyridinyl)methoxy]piperidino]butanoate | C23H29ClN2O3 | 详情 | 详情 | |
| (IV) | 16056 | 4-[4-[(4-chlorophenyl)(2-pyridinyl)methoxy]piperidino]butyric acid | C21H25ClN2O3 | 详情 | 详情 |
Extended Information