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【结 构 式】 
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【分子编号】16686 【品名】9-(3-benzyl-4-phenylbutyl)-6-cyclohexyl-2,3,4,9-tetrahydro-1H-carbazol-1-one 【CA登记号】 |
【 分 子 式 】C35H39NO 【 分 子 量 】489.7008 【元素组成】C 85.85% H 8.03% N 2.86% O 3.27% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reaction of 6-cyclohexyl-3,4-dihydro-2H-carbazol-1-one (I) with 2-dibenzylaminoethyl chloride by means of phase transfer catalysis using benzyltriethylammonium chloride and sodium hydroxide in chlorobenzene gives 6-cyclohexyl-9-[2-(dibenzylamino)ethyl-3,4-dihydro-2H-carbazol-1-one (II), which is reduced with H2 over palladium bis(acetonylacetonate) and carbon to give tetrindol.
| 【1】 Glushkov, R.G.; Mashkovsky, M.D.; Andrejeva, N.I.; Tetrindole. Drugs Fut 1997, 22, 12, 1333. |
| 【2】 Glushkov, R.G.; Design of new synthetic drugs: State of the art and prospects. Vestn Russ Acad Med Sci 1994, 11, 31-5. |
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