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【结 构 式】 
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【药物名称】Tetrindol, Tetrindole, Tetrindol 【化学名称】(±)-8-Cyclohexyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride 【CA登记号】135991-95-6 【 分 子 式 】C20H27ClN2 【 分 子 量 】330.90459 |
【开发单位】Center for Chemistry of Drugs (Originator), Russian Academy of Medical Sciences (Originator) 【药理作用】Antidepressants, Cognition Disorders, Treatment of, Mood Disorders, Treatment of, NEUROLOGIC DRUGS, PSYCHOPHARMACOLOGIC DRUGS, MAO-A Inhibitors |
合成路线1
The reaction of 6-cyclohexyl-3,4-dihydro-2H-carbazol-1-one (I) with 2-dibenzylaminoethyl chloride by means of phase transfer catalysis using benzyltriethylammonium chloride and sodium hydroxide in chlorobenzene gives 6-cyclohexyl-9-[2-(dibenzylamino)ethyl-3,4-dihydro-2H-carbazol-1-one (II), which is reduced with H2 over palladium bis(acetonylacetonate) and carbon to give tetrindol.
| 【1】 Glushkov, R.G.; Mashkovsky, M.D.; Andrejeva, N.I.; Tetrindole. Drugs Fut 1997, 22, 12, 1333. |
| 【2】 Glushkov, R.G.; Design of new synthetic drugs: State of the art and prospects. Vestn Russ Acad Med Sci 1994, 11, 31-5. |