1-[2-(2-Naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine -Drug Synthesis Database

【结构式】

【分子编号】13971

【品名】1-[2-(2-Naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

【CA登记号】

【分子式】C₂₄H₂₂F₃N

【分子量】381.4406296

【元素组成】C 75.57% H 5.81% F 14.94% N 3.67%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine (I) with 2-(2-naphthyl)acetyl chloride (II) by means of triethylamine in dichloromethane gives 1-[2-(2-naphthyl)acetyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6 tetrahydropyridine (III), which is finally reduced with LiAlH4 in ethyl ether.

参考文献中间体

合成目标

【1】 Castaner, J.; Mucke, H.A.M.; SR-57746A. Drugs Fut 1998, 23, 6, 616.
【2】 Nisato, D.; Frigerio, M.; Miranda, G.F. (Midy SpA; Sanofi-Synthelabo ); Trifluoromethylphenyltetrahydropyridines with anorexigenic activity, a process for their preparation and compsns. EP 0101381 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	13969	4-[3-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine	C₁₂H₁₂F₃N	详情	详情
(II)	13970	2-(2-Naphthyl)acetyl chloride	C₁₂H₉ClO	详情	详情
(III)	13971	1-[2-(2-Naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine	C₂₄H₂₂F₃N	详情	详情

Extended Information