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【结 构 式】 
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【分子编号】13969 【品名】4-[3-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine 【CA登记号】 |
【 分 子 式 】C12H12F3N 【 分 子 量 】227.2292296 【元素组成】C 63.43% H 5.32% F 25.08% N 6.16% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of 4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine (I) with 2-(2-naphthyl)acetyl chloride (II) by means of triethylamine in dichloromethane gives 1-[2-(2-naphthyl)acetyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6 tetrahydropyridine (III), which is finally reduced with LiAlH4 in ethyl ether.
| 【1】 Castaner, J.; Mucke, H.A.M.; SR-57746A. Drugs Fut 1998, 23, 6, 616. |
| 【2】 Nisato, D.; Frigerio, M.; Miranda, G.F. (Midy SpA; Sanofi-Synthelabo ); Trifluoromethylphenyltetrahydropyridines with anorexigenic activity, a process for their preparation and compsns. EP 0101381 . |
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