ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】10408

【品名】ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate

【CA登记号】

【分子式】C₁₃H₁₃NO₄

【分子量】247.25056

【元素组成】C 63.15% H 5.3% N 5.66% O 25.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

By condensation of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ethyl ester (I) with N-methylaniline (II) by heating at 125 C and distillation of the ethanol formed.

参考文献中间体

合成目标

【1】 Robinson, C.; Castaner, J.; Roquinimex. Drugs Fut 1995, 20, 1, 19.
【2】 Bargiotti, A.; Zini, P.; Penco, S.; Giuliani, F. (Pharmacia Corp.); Novel morpholino derivs. of daunorubicins and doxorubicins. BE 0904431; DE 3609052; GB 2172594; JP 1986221194; US 4672057 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10408	ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate		C₁₃H₁₃NO₄	详情	详情
(II)	10409	N-Methyl-N-phenylamine; N-methylaniline; Monomethylaniline	100-61-8	C₇H₉N	详情	详情

Extended Information