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【结 构 式】 
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【药物名称】Roquinimex, PNU-212616, FCF-89, LS-2616, Linomide 【化学名称】4-Hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydro-3-quinolinecarboxamide 【CA登记号】84088-42-6 【 分 子 式 】C18H16N2O3 【 分 子 量 】308.33982 |
【开发单位】Leo (Originator), Pfizer (Originator) 【药理作用】Antiarthritic Drugs, Immunologic Neuromuscular Disorders, Treatment of, IMMUNOMODULATING AGENTS, Immunostimulants, Multiple Sclerosis, Agents for, NEUROLOGIC DRUGS, ONCOLYTIC DRUGS, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Angiogenesis Inhibitors |
合成路线1
By condensation of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ethyl ester (I) with N-methylaniline (II) by heating at 125 C and distillation of the ethanol formed.
| 【1】 Robinson, C.; Castaner, J.; Roquinimex. Drugs Fut 1995, 20, 1, 19. |
| 【2】 Bargiotti, A.; Zini, P.; Penco, S.; Giuliani, F. (Pharmacia Corp.); Novel morpholino derivs. of daunorubicins and doxorubicins. BE 0904431; DE 3609052; GB 2172594; JP 1986221194; US 4672057 . |
Extended Information