1,3-Dioxalane; 1,3-Dioxolane -Drug Synthesis Database

【结构式】

【分子编号】10353

【品名】1,3-Dioxalane; 1,3-Dioxolane

【CA登记号】646-06-0

【分子式】C₃H₆O₂

【分子量】74.07944

【元素组成】C 48.64% H 8.16% O 43.2%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

An efficient and selective process for the synthesis of acyclovir has been published: The reaction of guanine (I) with refluxing hexamethyldisilazane (HMDS) (II) by means of trifluoromethanesulfonic acid, elimination of the HMDS in excess and condensation of the resulting product with refluxing 1,3-dioxolane (III) gives 9-[2-(trimethylsilyloxy)ethoxymethyl]guanine (IV), which is finally hydrolyzed with refluxing acetic acid/water.

参考文献中间体

合成目标

【1】 Han, Y.-K.; Harrington, P.J.; Schloemer, G.C. (F. Hoffmann-La Roche AG); Preparation of acyclovir. EP 0709385; JP 1996053451 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10352	2-Amino-1,9-dihydro-6H-purin-6-one; Guanine	73-40-5	C₅H₅N₅O	详情	详情
(III)	10353	1,3-Dioxalane; 1,3-Dioxolane	646-06-0	C₃H₆O₂	详情	详情
(IV)	10354	2-Amino-9-([2-[(trimethylsilyl)oxy]ethoxy]methyl)-1,9-dihydro-6H-purin-6-one		C₁₁H₁₉N₅O₃Si	详情	详情

Extended Information