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【结 构 式】

【分子编号】10353

【品名】1,3-Dioxalane; 1,3-Dioxolane

【CA登记号】646-06-0

【 分 子 式 】C3H6O2

【 分 子 量 】74.07944

【元素组成】C 48.64% H 8.16% O 43.2%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

An efficient and selective process for the synthesis of acyclovir has been published: The reaction of guanine (I) with refluxing hexamethyldisilazane (HMDS) (II) by means of trifluoromethanesulfonic acid, elimination of the HMDS in excess and condensation of the resulting product with refluxing 1,3-dioxolane (III) gives 9-[2-(trimethylsilyloxy)ethoxymethyl]guanine (IV), which is finally hydrolyzed with refluxing acetic acid/water.

1 Han, Y.-K.; Harrington, P.J.; Schloemer, G.C. (F. Hoffmann-La Roche AG); Preparation of acyclovir. EP 0709385; JP 1996053451 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10352 2-Amino-1,9-dihydro-6H-purin-6-one; Guanine 73-40-5 C5H5N5O 详情 详情
(III) 10353 1,3-Dioxalane; 1,3-Dioxolane 646-06-0 C3H6O2 详情 详情
(IV) 10354 2-Amino-9-([2-[(trimethylsilyl)oxy]ethoxy]methyl)-1,9-dihydro-6H-purin-6-one C11H19N5O3Si 详情 详情
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