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【结 构 式】 
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【分子编号】10352 【品名】2-Amino-1,9-dihydro-6H-purin-6-one; Guanine 【CA登记号】73-40-5 |
【 分 子 式 】C5H5N5O 【 分 子 量 】151.1278 【元素组成】C 39.74% H 3.33% N 46.34% O 10.59% |
合成路线1
该中间体在本合成路线中的序号：(I)An efficient and selective process for the synthesis of acyclovir has been published: The reaction of guanine (I) with refluxing hexamethyldisilazane (HMDS) (II) by means of trifluoromethanesulfonic acid, elimination of the HMDS in excess and condensation of the resulting product with refluxing 1,3-dioxolane (III) gives 9-[2-(trimethylsilyloxy)ethoxymethyl]guanine (IV), which is finally hydrolyzed with refluxing acetic acid/water.
| 【1】 Han, Y.-K.; Harrington, P.J.; Schloemer, G.C. (F. Hoffmann-La Roche AG); Preparation of acyclovir. EP 0709385; JP 1996053451 . |
合成路线2
该中间体在本合成路线中的序号：(I)The acetylation of guanine (I) or guanosine (II) with acetic anhydride gives the diacetyl guanine (III), which is condensed with 1,4-diacetoxy-2-oxabutane (IV) by means of TsOH to yield N,O-diacetyl acyclovir (V). Finally, this compound is deacetylated with NH3, NaOH or pyrrolidine at room temperature, or also with refluxing glycol.
| 【1】 Gao, H.; Mitra, A.K.; Synthesis of acyclovir, ganciclovir and their prodrugs: A review. Synthesis 2000, 3, 329. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10352 | 2-Amino-1,9-dihydro-6H-purin-6-one; Guanine | 73-40-5 | C5H5N5O | 详情 | 详情 |
| (II) | 38958 | Guanosine; 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one | 118-00-3 | C10H13N5O5 | 详情 | 详情 |
| (III) | 29161 | N-(9-acetyl-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide; N2,9-Diacetylguanine | 3056-33-5 | C9H9N5O3 | 详情 | 详情 |
| (IV) | 46052 | [2-(acetoxy)ethoxy]methyl acetate | C7H12O5 | 详情 | 详情 | |
| (V) | 10784 | 2-[[2-(acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl]methoxy]ethyl acetate; Acetic acid 2-(2-acetamido-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester | 75128-73-3 | C12H15N5O5 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XXII)The condensation of 1-acetoxy-2-(acetoxymethoxy)-3-(benzyloxy) propane (XXI) with guanine (XXII) by means of HMDS and trifluoromethanesulfonic acid gives O-acetyl-O'-benzylganciclovir (XXIII), which is deacetylated with NaOH in methanol to yield the previously reported mono-O-benzylganciclovir (XVIII). The preceding reaction sequence can also be performed by using 1-(benzyloxy)-2-(propionyloxymethoxy)-3-(propionyloxy)propane (XXIV) instead of compound (XXI), yielding intermediate (XXV) and finally the previously reported mono-O-benzylganciclovir (XVIII).
| 【1】 Sorbera, L.A.; Castañer, J.; Castañer, R.M.; Valganciclovir Hydrochloride. Drugs Fut 2000, 25, 5, 474. |
| 【2】 Dvorak, C.A.; Beard, C.C.; Wren, D.L.; Axt, S.D.; Han, Y.-K.; Fatheree, P.R.; Nguyen, S.L.; Lund, J.P.; Fisher, L.E.; Arzeno, H.B.; Humphreys, E.R. (F. Hoffmann-La Roche AG); Process for preparing purine derivs.. US 6040446; WO 9727198 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVIII) | 35324 | 2-amino-9-[[2-(benzyloxy)-1-(hydroxymethyl)ethoxy]methyl]-1,9-dihydro-6H-purin-6-one | C16H19N5O4 | 详情 | 详情 | |
| (XXI) | 35326 | [2-(acetoxy)-1-[(benzyloxy)methyl]ethoxy]methyl acetate | C15H20O6 | 详情 | 详情 | |
| (XXII) | 10352 | 2-Amino-1,9-dihydro-6H-purin-6-one; Guanine | 73-40-5 | C5H5N5O | 详情 | 详情 |
| (XXIII) | 35327 | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-(benzyloxy)propyl acetate | C18H21N5O5 | 详情 | 详情 | |
| (XXIV) | 35328 | 3-(benzyloxy)-2-[(propionyloxy)methoxy]propyl propionate | C17H24O6 | 详情 | 详情 | |
| (XXV) | 35329 | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-(benzyloxy)propyl propionate | C19H23N5O5 | 详情 | 详情 |