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【结 构 式】 
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【分子编号】10275 【品名】methyl 7-[[amino(imino)methyl]amino]heptanoate 【CA登记号】 |
【 分 子 式 】C9H19N3O2 【 分 子 量 】201.26888 【元素组成】C 53.71% H 9.52% N 20.88% O 15.9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The synthesis of [14C]-labeled 15-deoxyspergualin trihydrochloride has been reported: The condensation of [14C]-labeled S-methylisothiourea (I) with 7-aminoheptanoic acid (II) by means of NaOH in water gives 7-guanidinoheptanoic acid (III), which is treated with Dowex 50W resin (H+ form) in refluxing methanol yielding the corresponding methyl ester (IV). The reaction of (IV) with concentrated NH4OH affords the amide (V), which is finally condensed with glyoxyloxyspermidine (VI) by means of glutaric acid in hot water (60 C), and purified by chromatography over Sephadex CM-25 (Na+ form).
| 【1】 Dischino, D.D.; Synthesis of carbon-14 labeled (±) 15-deoxyspergualin trihydrochloride. J Label Compd Radiopharm 1995, 36, 11, 1097. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10272 | [[Amino(imino)methyl]sulfanyl]methane | 2986-19-8 | C2H6N2S | 详情 | 详情 |
| (I) | 44636 | [[amino(imino)methyl]sulfanyl]methane | C2H6N2S | 详情 | 详情 | |
| (II) | 10273 | 7-Aminoheptanoic acid | 929-17-9 | C7H15NO2 | 详情 | 详情 |
| (III) | 10274 | 7-[[Amino(imino)methyl]amino]heptanoic acid | C8H17N3O2 | 详情 | 详情 | |
| (III) | 44637 | 7-[[amino(imino)methyl]amino]heptanoic acid | C8H17N3O2 | 详情 | 详情 | |
| (IV) | 10275 | methyl 7-[[amino(imino)methyl]amino]heptanoate | C9H19N3O2 | 详情 | 详情 | |
| (IV) | 44638 | methyl 7-[[amino(imino)methyl]amino]heptanoate | C9H19N3O2 | 详情 | 详情 | |
| (V) | 10270 | 7-[[Amino(imino)methyl]amino]heptanamide | C8H18N4O | 详情 | 详情 | |
| (V) | 44639 | 7-[[amino(imino)methyl]amino]heptanamide | C8H18N4O | 详情 | 详情 | |
| (VI) | 10271 | N-[4-[(3-Aminopropyl)amino]butyl]-2,2-dihydroxyacetamide | C9H21N3O3 | 详情 | 详情 |
Extended Information