|
【结 构 式】 
|
【分子编号】10254 【品名】4-(2-bromoethoxy)benzoic acid 【CA登记号】51616-09-2 |
【 分 子 式 】C9H9BrO3 【 分 子 量 】245.07266 【元素组成】C 44.11% H 3.7% Br 32.6% O 19.59% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)A new synthesis of dazoxiben has been described: The condensation of methyl 4-hydroxybenzoate (I) with 1,2-dibromoethane (II) by means of NaOH gives methyl 4-(2-bromoethoxy)benzoate (III), which is hydrolyzed with H2SO4 to the corresponding free acid (IV). Finally, this compound is condensed with imidazole (V) in refluxing butanol.
| 【1】 Palei, R.M.; Kochergin, P.M.; Balandina, L.V.; Govorukhina, E.I.; Persanova, L.V.; Frolova, M.A.; Kravchenko, A.N.; Kharitonova, A.E.; A simplified synthesis of dazoxibene. Khim Farm Zh 1995, 29, 2, 56. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10251 | methyl 4-hydroxybenzoate; Methyl p-hydroxybenzoate | 99-76-3 | C8H8O3 | 详情 | 详情 |
| (II) | 10252 | 1,2-Dibromoethane; Ethylene dibromide | 106-93-4 | C2H4Br2 | 详情 | 详情 |
| (III) | 10253 | methyl 4-(2-bromoethoxy)benzoate | 56850-91-0 | C10H11BrO3 | 详情 | 详情 |
| (IV) | 10254 | 4-(2-bromoethoxy)benzoic acid | 51616-09-2 | C9H9BrO3 | 详情 | 详情 |
| (V) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
Extended Information