methyl 4-(2-bromoethoxy)benzoate -Drug Synthesis Database

【结构式】

【分子编号】10253

【品名】methyl 4-(2-bromoethoxy)benzoate

【CA登记号】56850-91-0

【分子式】C₁₀H₁₁BrO₃

【分子量】259.09954

【元素组成】C 46.36% H 4.28% Br 30.84% O 18.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

A new synthesis of dazoxiben has been described: The condensation of methyl 4-hydroxybenzoate (I) with 1,2-dibromoethane (II) by means of NaOH gives methyl 4-(2-bromoethoxy)benzoate (III), which is hydrolyzed with H2SO4 to the corresponding free acid (IV). Finally, this compound is condensed with imidazole (V) in refluxing butanol.

参考文献中间体

合成目标

【1】 Palei, R.M.; Kochergin, P.M.; Balandina, L.V.; Govorukhina, E.I.; Persanova, L.V.; Frolova, M.A.; Kravchenko, A.N.; Kharitonova, A.E.; A simplified synthesis of dazoxibene. Khim Farm Zh 1995, 29, 2, 56.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10251	methyl 4-hydroxybenzoate; Methyl p-hydroxybenzoate	99-76-3	C₈H₈O₃	详情	详情
(II)	10252	1,2-Dibromoethane; Ethylene dibromide	106-93-4	C₂H₄Br₂	详情	详情
(III)	10253	methyl 4-(2-bromoethoxy)benzoate	56850-91-0	C₁₀H₁₁BrO₃	详情	详情
(IV)	10254	4-(2-bromoethoxy)benzoic acid	51616-09-2	C₉H₉BrO₃	详情	详情
(V)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情

Extended Information