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【结 构 式】 
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【药物名称】 【化学名称】9-Ethyl-9H-carbazole-3-carbaldehyde O-[2-[(E)-(3,4-dihydroxybenzylidene)aminooxy]ethyl]oxime 【CA登记号】 【 分 子 式 】C24H23N3O4 【 分 子 量 】417.46861 |
【开发单位】University of California, Berkeley (Originator), University of Pennsylvania (Originator) 【药理作用】PHARMACOLOGICAL TOOLS, Src Kinase Inhibitors |
合成路线1
The title compound was obtained by condensation between 9-ethylcarbazole-3-carboxaldehyde (I), veratraldehyde (III), and O,O'-diaminoethanediol (II). The desired asymmetric bisoxime was separated from the symmetric homodimers by silica gel column chromatography.
| 【1】 Choong, I.C.; Dustin, J.; Ellman, J.A.; Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors. Proceedings of the National Academy of Sciences of the United States of America 2000, 97, 6, 2419. |
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