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【结 构 式】 
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【药物名称】L44 【化学名称】Pyridine-3-carboxylic acid 2-tert-butyl-4-cyclohexylphenyl ester 【CA登记号】79781-87-6 【 分 子 式 】C22H27NO2 【 分 子 量 】337.46599 |
【开发单位】Merz (Originator) 【药理作用】Lipoprotein Disorders, Treatment of , METABOLIC DRUGS, Non-Steroidal Antiinflammatory Drugs |
合成路线1
L44 is prepared by alkylating p-cyclohexylphenol (I) with iosobutene using Aberlyst A 15 as a catalyst. The raw mixture (II) is esterified with nicotinoyl chloride hydrochloride (III). The product is purified by recristallization from ethanol.
| 【1】 Quack, G.; L44/L44-O. Drugs Fut 1987, 12, 4, 349. |
Extended Information