|
【结 构 式】 
|
【药物名称】Precedex;Dexmedetomidine 【化学名称】lH-Imidazole,4-[ (lS)-l-(2,3-dimethylphenyl) ethyll-: morwhydrochloride (9CI)}; lH-Imidazole, 4-[1-(2,3-dimethylphenyl) ethyl]-,monohyckochloride, (S)-; 【CA登记号】145108-58-3 【 分 子 式 】C13H16N2.HCl 【 分 子 量 】238.7405 |
【开发单位】Abbott Labs 【药理作用】sedative-hypnotic |
合成路线1
| 【1】 Karjalainen AJ, Pohjala EK, et aL 1983. Substituted imidazole derivatives and their use. GB Pat 2101114 |
| 【2】 Karjalainen AJ, Virtanen RE, et aL 1989. Preparation and testing of medetomidine enantiomers as CNS agents GB Pat. 2206880 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27998 | methyl 1H-imidazole-4-carboxylate | 17325-26-7 | C5H6N2O2 | 详情 | 详情 |
| (II) | 27999 | bromo(2,3-dimethylphenyl)magnesium | C8H9BrMg | 详情 | 详情 | |
| (III) | 66258 | 1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-yl)ethanol | C13H16N2O | 详情 | 详情 | |
| (IV) | 66259 | 4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole | C13H16N2 | 详情 | 详情 |
合成路线2
| 【1】 Kudzma LV, Turnbull SP. 1991. Expedient synthesis of 4(5)-[l-(2,3-dimethylphCnyl)-lH-midazole,the α2-adrenergic agonist medetomidine. Synthesis, 1021---1022 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11036 | N,N-Dimethyl-1H-imidazole-1-sulfonamide | 78162-58-0 | C5H9N3O2S | 详情 | 详情 |
| (II) | 11038 | 2,3-Dimethylbenzoyl chloride | 21900-46-9 | C9H9ClO | 详情 | 详情 |
| (III) | 66260 | 5-(2,3-dimethylbenzoyl)-N,N-dimethyl-2-(2,3,3-trimethylbutan-2-yl)-1H-imidazole-1-sulfonamide | C21H31N3O3S | 详情 | 详情 | |
| (IV) | 11040 | (2,3-Dimethylphenyl)(1H-imidazol-4-yl)methanone | C12H12N2O | 详情 | 详情 | |
| (V) | 66259 | 4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole | C13H16N2 | 详情 | 详情 |
Extended Information