【结 构 式】 |
【分子编号】69308 【品名】1(S)-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 【CA登记号】 |
【 分 子 式 】C11H14N2O 【 分 子 量 】190.245 【元素组成】C 69.45% H 7.42% N 14.72% O 8.41% |
合成路线1
该中间体在本合成路线中的序号:(II)Racemic amine (I) can be resolved by the following alternative procedures:
【1】 Koenig, T.M., Nissen, J.S., Mitchell, D. (Eli Lilly and Company). Lactam compound. EP 1345955, JP 2005538031, WO 2002040508. |
【2】 Audia, J.E., John, V., Latimer, L.H., Tung, J.S., Nissen, J.S., Thorsett, E.D., McDaniel, S.L. (Eli Lilly and Company; Elan Pharmaceuticals, Inc.). Lactam compound. JP 2004517090, WO 2002047671. |
【3】 Koenig, T.M., Audia, J.E., Mitchell, D., Aikins, J.A., Buccilli, L.A., Engel,G.L., McDaniel, S.L. (Eli Lilly and Company). Lactam compound. CA 2425497, EP 1353910, JP 2004521084, WO 2002040451. |
【4】 Audia, J.E., Diseroad, B.A., Varghese, J. et al. (Eli Lilly and Company).Lactam compound. US 2007299053, US 7468365. |
【5】 Mitchell, D., Hay, L.A., Koenig, T.M., McDaniel, S., Nissen, J.S., Audia, J.E.Classical and dynamic resolution of 1-amino-3-methyl-1,3,4,5-tetrahydrobenzo[d]azepin-2-one. Tetrahedron Asymmetry 2005, 16(23): 3814-9. |
【6】 Pu, Y.J., Vaid, R.K., Boini, S.K., Towsley, R.W., Doecke, C.W., Mitchell, D. A practical method for functionalized peptide or amide bond formation in aqueous-ethanol media with EDC as activator. Org Process Res Dev 2009, 13(2): 310-4. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 69307 | 1-amino-3-methyl-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one | C11H14N2O | 详情 | 详情 | |
(II) | 69308 | 1(S)-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one | C11H14N2O | 详情 | 详情 | |
(III) | 69309 | 1(S)-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one | C11H14N2O | 详情 | 详情 | |
(IV) | 26450 | Boc-L-Alanine;(S)-2-((tert-butoxycarbonyl)amino)propanoic acid;N-Boc-L-alanine; (2S)-2-[(tert-butoxycarbonyl)amino]propionic acid | 15761-38-3 | C8H15NO4 | 详情 | 详情 |
(V) | 13423 | 1-[(Chlorocarbonyl)oxy]-2-methylpropane; Isobutyl chloroformate;isobutyl carbonochloridate | 543-27-1 | C5H9ClO2 | 详情 | 详情 |
(VI) | 69310 | (S)-2-((tert-butoxycarbonyl)amino)propanoic (isobutyl carbonic) anhydride | C13H23NO6 | 详情 | 详情 | |
(VII) | 69311 | (S)-2-amino-N-((R)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)propanamide hydrochloride | C14H19N3O2.HCl | 详情 | 详情 | |
(VIII) | 69312 | (S)-2-amino-N-((R)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)propanamide methanesulfonate | C14H19N3O2.CH4O3S | 详情 | 详情 | |
(IX) | 69313 | tert-butyl ((S)-1-(((R)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)amino)-1-oxopropan-2-yl)carbamate | C19H27N3O4 | 详情 | 详情 | |
(X) | 69314 | 2(S)-hydroxy-3-methylbutyric acid | C5H10O3 | 详情 | 详情 | |
(XI) | 69315 | (S)-trimethylsilyl 3-methyl-2-((trimethylsilyl)oxy)butanoate | C11H26O3Si2 | 详情 | 详情 |