【结 构 式】 |
【分子编号】69202 【品名】2-(2-hydroxy-4-nitrophenyl)isoindoline-1,3-dione 【CA登记号】 |
【 分 子 式 】C14H8N2O5 【 分 子 量 】284.228 【元素组成】C 59.16% H 2.84% N 9.85% O 28.14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XIX)The intermediate N-(2-ethoxy-4-nitrophenyl)phthalimide (IV) is prepared by N-protection of 2-amino-5-nitrophenol (XVII) with phthalic anhydride (XVIII) in the presence of AcOH at 115-120 °C to give the corresponding phthalimide (XIX), which is then alkylated at the phenolic hydroxyl with ethyl bromide (XX) in the presence of K2CO3 in DMF .
【1】 Chew, W., Papamichelakis, M. (Wyeth). Methods of preparing 3-cyanoquinolines and intermediates made thereby. WO 2006127205. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(IV) | 69192 | 2-(2-ethoxy-4-nitrophenyl)isoindoline-1,3-dione | C16H12N2O5 | 详情 | 详情 | |
(XVII) | 33067 | 2-amino-5-nitrophenol | 121-88-0 | C6H6N2O3 | 详情 | 详情 |
(XVIII) | 11900 | 2-Benzofuran-1,3-dione;1,2-Benzenedicarboxylic Anhydride;1,2-BENZENE DICARBOXYLIC ACID ANHYDRIDE;1,2-BENZENEDICARBONIC ACID, ANHYDRIDE;1,3-DIOXOPHTHALAN;1,3-ISOBENZOFURANDIONE;o-phthalic anhydride; Phthalic anhydride | 85-44-9 | C8H4O3 | 详情 | 详情 |
(XIX) | 69202 | 2-(2-hydroxy-4-nitrophenyl)isoindoline-1,3-dione | C14H8N2O5 | 详情 | 详情 | |
(XX) | 30344 | 1-bromoethane;ethyl bromide | 74-96-4 | C2H5Br | 详情 | 详情 |
Extended Information