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【结 构 式】

【分子编号】68105

【品名】N,N-di-Boc-5-bromopyrimidin-2-amine;Imidodicarbonicacid, 2-(5-bromo-2-pyrimidinyl)-, 1,3-bis(1,1-dimethylethyl) ester;Imidodicarbonicacid, (5-bromo-2-pyrimidinyl)-, bis(1,1-dimethylethyl) ester (9CI);(5-Bromopyrimidin-2-yl)bis(tert-butoxycarbonyl)amine

【CA登记号】209959-33-1

【 分 子 式 】C14H20BrN3O4

【 分 子 量 】374.235

【元素组成】C 44.93% H 5.39% Br 21.35% N 11.23% O 17.10%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVII)

The key intermediate (XIII) is prepared by N-protection of 5-bromopyrimidin-2-amine (XVI) with Boc2o by means of DMAP in DMF to give N,N-di-Boc-5-bromopyrimidin-2-amine (XVII), which by metalation with BuLi in THF, followed by borylation with (i-Pro)3B provides the pyrimidin-5-ylboronic acid derivative (XVIII). Hydrolysis of protected amine (XVIII) with methanolic HCl affords 2-aminopyrimidin-5-ylboronic acid (IV), which is finally cyclized with pinacol (XX) in refluxing toluene or xylene .

1 Xu, J., Lai, W., Yang, B., Gu, S. (Jiangsu ChemFuture Pharma Tech. Co., Ltd.). Synthesis method of 2-amino-5-pyridineboronic acid pinacol ester. Cn 102399235
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 68102 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 402960-38-7 C10H16BN3O2 详情 详情
(XVI) 34822 5-bromo-2-pyrimidinamine; 5-bromo-2-pyrimidinylamine 7752-82-1 C4H4BrN3 详情 详情
(XVII) 68105 N,N-di-Boc-5-bromopyrimidin-2-amine;Imidodicarbonicacid, 2-(5-bromo-2-pyrimidinyl)-, 1,3-bis(1,1-dimethylethyl) ester;Imidodicarbonicacid, (5-bromo-2-pyrimidinyl)-, bis(1,1-dimethylethyl) ester (9CI);(5-Bromopyrimidin-2-yl)bis(tert-butoxycarbonyl)amine 209959-33-1 C14H20BrN3O4 详情 详情
(XVIII) 68106     C14H22BN3O6 详情 详情
(XIX) 68107 (2-aminopyrimidin-5-yl)boronic acid   C4H6BN3O2 详情 详情
(XX) 68108 2,3-Dimethyl-2,3-butanediol;2,3-Dimethylbutane-2,3-diol;Tetramethylethylene glycol;pinacol 76-09-5 C6H14O2 详情 详情
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