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【结 构 式】 
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【分子编号】68068 【品名】(R,E)-1-chloro-3-((4-chlorobenzylidene)amino)propan-2-ol 【CA登记号】 |
【 分 子 式 】C10H11Cl2NO 【 分 子 量 】232.10888 【元素组成】C 51.75% H 4.78% Cl 30.55% N 6.03% O 6.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XV)Intermediate (XIb) is prepared by condensation of 4-chlorobenzaldehyde (XIII) with NH4OH and (S)-(+)-epichlorohydrin (XIV) in MTBE or MeOH to yield imine (XV). Then imine (XV) is condensed with carbamate (VI) using t-BuOLi to give the 2-oxazolidinone derivative (XVI), which is finally hydrolyzed with HCl in EtOAc/H2O .
| 【1】 Brickner, S.J., Nuermberger, E., Stover, C.K. (Pfizer, Inc.). Combination therapy for tuberculosis. CN 102143748, EP 2340022, JP 20122502017, KR 2011063518, US 2011190199, WO 2010026526. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIb) | 68067 | (R)-5-(aminomethyl)-3-(3-fluoro-4-thiomorpholinophenyl)oxazolidin-2-one hydrochloride | C14H18FN3O2S.HCl | 详情 | 详情 | |
| (VI) | 68062 | benzyl (3-fluoro-4-thiomorpholinophenyl)carbamate | C18H19FN2O2S | 详情 | 详情 | |
| (XIII) | 29029 | 4-chlorobenzaldehyde | 104-88-1 | C7H5ClO | 详情 | 详情 |
| (XIV) | 13917 | (S)-Epichlorohydrin; (2S)-2-(Chloromethyl)oxirane;(S)-(+)-epichlorohydrin | 67843-74-7 | C3H5ClO | 详情 | 详情 |
| (XV) | 68068 | (R,E)-1-chloro-3-((4-chlorobenzylidene)amino)propan-2-ol | C10H11Cl2NO | 详情 | 详情 | |
| (XVI) | 68069 | (R,E)-5-(((4-chlorobenzylidene)amino)methyl)-3-(3-fluoro-4-thiomorpholinophenyl)oxazolidin-2-one | C21H21ClFN3O2S | 详情 | 详情 |
Extended Information