1-((8R,13R,14R)-17-hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl)ethanone -Drug Synthesis Database

【结构式】

【分子编号】67466

【品名】1-((8R,13R,14R)-17-hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl)ethanone

【CA登记号】　

【分子式】C₂₂H₃₀O₄

【分子量】358.4778

【元素组成】C 73.71% H 8.44% O 17.85%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号： (V)

【1】 Dancsi L, Visky G, Tuba Z, et al.2007.Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethylamino) Phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process. WO 2007144674 A1.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(V)	67466	1-((8R,13R,14R)-17-hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl)ethanone		C₂₂H₃₀O₄	详情	详情
(I)	30502	3,3-Ethylenedioxyestra-5(10),9(11)-dien-17-one	5571-36-8	C₂₀H₂₆O₃	详情	详情
(II)	67463	(8R,13R,14R,17S)-17-ethynyl-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol		C₂₂H₂₈O₃	详情	详情
(III)	67464	(8R,13R,14R)-13-methyl-17-(2-(phenylsulfinyl)vinylidene)-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]		C₂₈H₃₂O₃S	详情	详情
(IV)	67465	(8R,13R,14R)-17-(1-methoxyvinyl)-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol		C₂₃H₃₂O₄	详情	详情
(VI)	40868			C₂₄H₃₄O₅	详情	详情
(VII)	40869			C₂₄H₃₄O₆	详情	详情
(VIII)	40870			C₃₂H₄₅NO₆	详情	详情
(IX)	40871	(13S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one		C₂₈H₃₅NO₃	详情	详情

该中间体在本合成路线中的序号：(III)

【1】 Kim H, Pemmaraju N, Simmons Anne-Marie.2004.Process for the preparation of 17α-acetoxy-11β-[4-(N,N-dimethylamino) phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process. WO 2004078709 A2.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	40867	(13S,17R)-17-acetyl-17-hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one	14340-01-3	C₂₀H₂₆O₃	详情	详情
(II)	67474	(13R,17S)-17-acetyl-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate		C₂₂H₂₈O₄	详情	详情
(III)	67466	1-((8R,13R,14R)-17-hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl)ethanone		C₂₂H₃₀O₄	详情	详情
(IV)	67475	1-((5S,10S,13R,17S)-17-hydroxy-13- methyl-1,2,4,6,7,8,12,13,14,15,16,17- dodecahydrospiro[5,10-epoxycyclopenta[a] phenanthrene-3,2'-[1,3]dioxolan]-17-yl)ethanone		C₂₂H₃₀O₅	详情	详情
(V)	67476	1-((5S,13R,17S)-11-(4-(dimethylamino) phenyl)-5,17-dihydroxy-13-methyl- 1,2,4,5,6,7,8,11,12,13,14,15,16,17- tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'- [1,3]dioxolan]-17-yl)ethanone		C₃₀H₄₁NO₅	详情	详情

Extended Information