(2S,3S,11bS)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol -Drug Synthesis Database

【结构式】

【分子编号】67443

【品名】(2S,3S,11bS)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol

【CA登记号】　

【分子式】C₁₉H₂₉NO₃

【分子量】319.4442

【元素组成】C 71.44% H 9.15% N 4.38% O 15.03%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

【1】 Boldt KG, Biggers MS, Phifer SS, et al.2009.Synthesis of (+)- and (-)-tetrabenazine from the resolution of α-dihydrotetrabenazine. Synthetic Commun,39, 3574～3585.
【2】 Gant TG, Shahbaz M.2010.Benzoquinoline inhibitors of vesicular monoamine transporter 2.WO 2010/044981 A2.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47677	2-Methyl-5-Hexanone; 5-Methyl-2-hexanone; 5-Methyl-2-oxohexane; iso-Amyl methyl ketone; Isopentyl methyl ketone; Methyl isoamyl ketone	110-12-3	C₇H₁₄O	详情	详情
(II)	67440	3-((dimethylamino)methyl)-5-methylhexan-2-one	91342-74-4	C₁₀H₂₁NO	详情	详情
(III)	67441	2-acetyl-N,N,N,4-tetramethylpentan-1-aminium iodide		C₁₁H₂₄INO	详情	详情
(IV)	10098	2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine	120-20-7	C₁₀H₁₅NO₂	详情	详情
(V)	67442	6,7-dimethoxy-3,4-dihydroisoquinoline	3382-18-1	C₁₁H₁₃NO₂	详情	详情
(VII)	67443	(2S,3S,11bS)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol		C₁₉H₂₉NO₃	详情	详情

Extended Information