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【结 构 式】 
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【分子编号】67383 【品名】ethyl 1-(9-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-(((E)-3-ethoxy-2-formyl-3-oxoprop-1-en-1-yl)amino)-9H-purin-2-yl)-1H-pyrazole-4-carboxylate 【CA登记号】 |
【 分 子 式 】C22H25N7O9 【 分 子 量 】531.482 【元素组成】C 49.72% H 4.74% N 18.45% O 27.09% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)
| 【1】 Schaeffer HJ, Thomas HJ. 1958. Synthesis of potential anticancer agents XIV. Ribosides of 2,6-disubstituted purines. J Am Chem Soc, 80: 3738～3741. |
| 【2】 Zablocki J, Elzein E. 2007. Process for preparaing an A2A-adenosine receptor agonist and its polymorphs. WO 2007/092372A1 (CV Therapeutics Inc). |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25254 | 2,6-dichloro-9H-purine | 5451-40-1 | C5H2Cl2N4 | 详情 | 详情 |
| (III) | 67380 | (2R,3R,4R,5R)-2-acetoxy-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate | 14215-97-5 | C28H24O9 | 详情 | 详情 |
| (IV) | 67381 | (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-chlorotetrahydrofuran-3,4-diyl dibenzoate | C26H21ClO7 | 详情 | 详情 | |
| (V) | 32565 | (2R,3R,4R,5R)-4-(benzoyloxy)-2-[(benzoyloxy)methyl]-5-(2,6-dichloro-9H-purin-9-yl)tetrahydro-3-furanyl benzoate | C31H22Cl2N4O7 | 详情 | 详情 | |
| (VI) | 67382 | (3R,4R,5R)-2-(2,6-dichloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | 13276-52-3 | C10H10Cl2N4O4 | 详情 | 详情 |
| (VII) | 54960 | (2R,3R,4S,5R)-2-(6-amino-2-hydrazino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol | C10H15N7O4 | 详情 | 详情 | |
| (VIII) | 67383 | ethyl 1-(9-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-(((E)-3-ethoxy-2-formyl-3-oxoprop-1-en-1-yl)amino)-9H-purin-2-yl)-1H-pyrazole-4-carboxylate | C22H25N7O9 | 详情 | 详情 |
Extended Information