9-(3-(2-bromo-4-fluorophenoxy)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propyl)-9-borabicyclo[3.3.1]nonane -Drug Synthesis Database

【结构式】

【分子编号】67311

【品名】9-(3-(2-bromo-4-fluorophenoxy)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propyl)-9-borabicyclo[3.3.1]nonane

【CA登记号】　

【分子式】C₂₂H₃₁BBrFO₃

【分子量】453.2

【元素组成】C 58.31% H 6.89% B 2.38% Br 17.63% F 4.19% O 10.59%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

【1】 Volpicelli R, Maragni P, Cotarca L, et al.2008.Process for preparation nebivolol. WO 2008064827.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36759	(4R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde	15186-48-8	C₆H₁₀O₃	详情	详情
(II)	67309	1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-2-en-1-ol		C₈H₁₄O₃	详情	详情
(III)	67310	(4S)-4-(1-(2-bromo-4-fluorophenoxy)allyl)-2,2-dimethyl-1,3-dioxolane		C₁₄H₁₆BrFO₃	详情	详情
(IV)	67311	9-(3-(2-bromo-4-fluorophenoxy)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propyl)-9-borabicyclo[3.3.1]nonane		C₂₂H₃₁BBrFO₃	详情	详情
(V)	67312	2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-6-fluorochroman		C₁₄H₁₇FO₃	详情	详情
(VI)	67313	(S)-1-((R)-6-fluorochroman-2-yl)ethane-1,2-diol		C₁₁H₁₃FO₃	详情	详情
(VII)	67314	(S)-1-((S)-6-fluorochroman-2-yl)ethane-1,2-diol		C₁₁H₁₃FO₃	详情	详情
(VIII)	67315	(S)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl 4-methylbenzenesulfonate		C₁₈H₁₉FO₅S	详情	详情
(IX)	67316			C₁₁H₁₁FO₂	详情	详情
(X)	67317	2-(benzylamino)-1-(6-fluorochroman-2-yl)ethanol		C₁₈H₂₀FNO₂	详情	详情
(XI)	40857	(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl 4-methylbenzenesulfonate		C₁₈H₁₉FO₅S	详情	详情
(XII)	67300	(R)-6-fluoro-2-((R)-oxiran-2-yl)chroman		C₁₁H₁₁FO₂	详情	详情
(XIII)	67318	(S)-1-((R)-6-fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)(phenyl)amino)ethanol		C₂₈H₂₉F₂NO₄	详情	详情

Extended Information