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【结 构 式】 
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【分子编号】67292 【品名】(1R,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid 【CA登记号】 |
【 分 子 式 】C11H12O3 【 分 子 量 】192.21448 【元素组成】C 68.74% H 6.29% O 24.97% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)
| 【1】 Bonnaud B, Cousse H, Mouzin G, et al. 1987. 1-Aryl-2-(aminomethyl) cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. J Med Chem, 30: 318～325. |
| 【2】 Shi ZH, Ning Q, Zhou WC.2005.Synthesis of trans isomers of milnacipran hydrochloride. Farming Zhuanli Shenqing Gongkai Shoumingshu. CN1699332. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17046 | Phenylacetonitrile; 2-phenylacetonitrile; Benzyl cyanide | 140-29-4 | C8H7N | 详情 | 详情 |
| (II) | 67292 | (1R,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid | C11H12O3 | 详情 | 详情 | |
| (III) | 61470 | (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one | 63106-93-4 | C11H10O2 | 详情 | 详情 |
| (IV) | 67292 | (1R,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid | C11H12O3 | 详情 | 详情 | |
| (V) | 67293 | (1R,2R)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid | C11H11BrO2 | 详情 | 详情 | |
| (VI) | 67294 | (1R,2R)-2-(bromomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide | C15H20BrNO | 详情 | 详情 | |
| (VII) | 67295 | (1S,2S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-1-phenylcyclopropanecarboxylic acid | C19H15NO4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(IV)
| 【1】 Bonnaud B, Cousse H, Mouzin G, et al. 1987. 1-Aryl-2-(aminomethyl) cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. J Med Chem, 30: 318～325. |
| 【2】 Shi ZH, Ning Q, Zhou WC.2005.Synthesis of trans isomers of milnacipran hydrochloride. Farming Zhuanli Shenqing Gongkai Shoumingshu. CN1699332. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17046 | Phenylacetonitrile; 2-phenylacetonitrile; Benzyl cyanide | 140-29-4 | C8H7N | 详情 | 详情 |
| (II) | 67292 | (1R,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid | C11H12O3 | 详情 | 详情 | |
| (III) | 61470 | (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one | 63106-93-4 | C11H10O2 | 详情 | 详情 |
| (IV) | 67292 | (1R,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid | C11H12O3 | 详情 | 详情 | |
| (V) | 67293 | (1R,2R)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid | C11H11BrO2 | 详情 | 详情 | |
| (VI) | 67294 | (1R,2R)-2-(bromomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide | C15H20BrNO | 详情 | 详情 | |
| (VII) | 67295 | (1S,2S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-1-phenylcyclopropanecarboxylic acid | C19H15NO4 | 详情 | 详情 |
Extended Information