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【结 构 式】 
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【分子编号】67284 【品名】 (4S,4aR,7aS,12bR)-3-(cyclopropylmethyl)-4a-hydroxy-9-(isobutyryloxy)-3-methyl-7-oxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium iodide 【CA登记号】 |
【 分 子 式 】C25H32INO5 【 分 子 量 】553.437 【元素组成】C 54.26% H 5.83% I 22.93% N 2.53% O 14.45% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)
| 【1】 Doshan HD, Perez J. 2006. Synthesis of (R)-N-methylnaltrexone. WO 2006127899. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25079 | (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10-trien-14-one; Naltrexone | 16590-41-3 | C20H23NO4 | 详情 | 详情 |
| (II) | 67283 | (4S,4aR,7aS,12bR)-3-(cyclopropylmethyl)-4a-hydroxy-7-oxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl isobutyrate | C24H29NO5 | 详情 | 详情 | |
| (III) | 67284 | (4S,4aR,7aS,12bR)-3-(cyclopropylmethyl)-4a-hydroxy-9-(isobutyryloxy)-3-methyl-7-oxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium iodide | C25H32INO5 | 详情 | 详情 | |
| (IV) | 67282 | (4S,4aR,7aS,12bR)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-7-oxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium bromide | C21H27BrNO4 | 详情 | 详情 |
Extended Information