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【结 构 式】 
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【分子编号】67149 【品名】（E）-4-[(2,4-difluorophenyl)(hydroxyimino)methyl]-1-piperidinecarbaldehyde 【CA登记号】 |
【 分 子 式 】C13H14F2N2O2 【 分 子 量 】268.26324 【元素组成】C 58.21% H 5.26% F 14.16% N 10.44% O 11.93% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)
| 【1】 Strupczewski JT, Allen RC, Gardner BA, et al. 1985. Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles. J Med Chem, 28(6) : 761～769. |
| 【2】 Strupczewski JT, Bordeau KJ, Chiang YL, et al. 1995. 3-[[(aryloxy) alkyl] piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone. J Med Chem, 38(7): 1119～1131. |
| 【3】 Walsh DA, Franzyshen SK, Yanni JM. 1989. Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy) propyl] piperidines and structurally related compounds. J Med Chem, 32(1): 105～118. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 22605 | 4-(3-Chloropropoxy)-3-Methoxyacetophenone;3-(4-Acetyl-2-methoxyphenoxy)propyl chloride;1-(4-(3-chloropropoxy)-3-methoxyphenyl)ethanone;1-[4-(3-chloropropoxy)-3-methoxyphenyl]-1-ethanone | 58113-30-7 | C12H15ClO3 | 详情 | 详情 |
| (X) | 32035 | 4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinecarbaldehyde | C13H13FN2O2 | 详情 | 详情 | |
| (I) | 22604 | 1-(4-hydroxy-3-methoxyphenyl)-1-ethanone；Acetovanillone;4’-hydroxy-3’-methoxyacetophenone;1-(4-hydroxy-3-methoxyphenyl)ethanone | 498-02-2 | C9H10O3 | 详情 | 详情 |
| (III) | 17402 | 4-nipecotic acid;piperidine-4-carboxylic acid;p-nipecotic acid; Isonipecotic acid; Hexahydroisonicotinic acid; 4-Piperidinecarboxylic acid | 498-94-2 | C6H11NO2 | 详情 | 详情 |
| (IV) | 32031 | 1-Formyl-4-piperidinecarboxylic acid | 84163-42-8 | C7H11NO3 | 详情 | 详情 |
| (V) | 32032 | 1-formyl-4-piperidinecarbonyl chloride | C7H10ClNO2 | 详情 | 详情 | |
| (VI) | 13095 | m-Difluorobenzene; 1,3-Difluorobenzene | 372-18-9 | C6H4F2 | 详情 | 详情 |
| (VII) | 32033 | 4-(2,4-difluorobenzoyl)-1-piperidinecarbaldehyde | C13H13F2NO2 | 详情 | 详情 | |
| (VIII) | 32034 | 4-[(2,4-difluorophenyl)(hydroxyimino)methyl]-1-piperidinecarbaldehyde | C13H14F2N2O2 | 详情 | 详情 | |
| (IX) | 67149 | （E）-4-[(2,4-difluorophenyl)(hydroxyimino)methyl]-1-piperidinecarbaldehyde | C13H14F2N2O2 | 详情 | 详情 | |
| (XI) | 17910 | 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole | C12H13FN2O | 详情 | 详情 |
Extended Information