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【结 构 式】 
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【分子编号】67105 【品名】4-(3-(dibutylamino)propoxy)benzoyl chloride hydrochloride 【CA登记号】 |
【 分 子 式 】C18H28ClNO2.HCl 【 分 子 量 】362.339 【元素组成】C 59.67% H 8.07% Cl 19.57% N 3.86% O 8.83% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(VI)
| 【1】 Gutman AL, Nisnevich G, Yudovitch L.2003.Process for the perparation of dronedarone. WO 2003/040120; US 5223510; WO 9717346. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10251 | methyl 4-hydroxybenzoate; Methyl p-hydroxybenzoate | 99-76-3 | C8H8O3 | 详情 | 详情 |
| (II) | 12581 | 1,3-Dibromopropane | 109-64-8 | C3H6Br2 | 详情 | 详情 |
| (III) | 67102 | methyl 4-(3-bromopropoxy)benzoate | 135998-88-8 | C11H13BrO3 | 详情 | 详情 |
| (IV) | 67103 | methyl 4-(4-(dibutylamino)butyl)benzoate | C20H33NO2 | 详情 | 详情 | |
| (V) | 67104 | 4-(3-(dibutylamino)propoxy)benzoic acid hydrochloride | C18H29NO3.HCl | 详情 | 详情 | |
| (VI) | 67105 | 4-(3-(dibutylamino)propoxy)benzoyl chloride hydrochloride | C18H28ClNO2.HCl | 详情 | 详情 | |
| (VII) | 10478 | p-Anisidine; 4-Methoxyaniline; 4-Methoxyphenylamine | 104-94-9 | C7H9NO | 详情 | 详情 |
| (VIII) | 67106 | N-(4-methoxyphenyl)acetamide | 51-66-1 | C9H11NO2 | 详情 | 详情 |
| (IX) | 67107 | 2-bromohexanoyl chloride | 42768-46-7 | C6H10BrClO | 详情 | 详情 |
| (X) | 67108 | N-(2-(2-bromohexanoyl)-4-hydroxyphenyl)acetamide | C14H18BrNO3 | 详情 | 详情 | |
| (XI) | 67109 | N-(2-butyl-3-hydroxy-2,3-dihydrobenzofuran-6-yl)acetamide | C14H19NO3 | 详情 | 详情 | |
| (XII) | 67110 | N-(2-butylbenzofuran-6-yl)acetamide | C14H17NO2 | 详情 | 详情 | |
| (XIII) | 67111 | 2-butylbenzofuran-6-amine hydrochloride | C12H15NO.HCl | 详情 | 详情 | |
| (XIV) | 67112 | N-(2-butylbenzofuran-6-yl)methanesulfonamide | C13H17NO3S | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VII)
| 【1】 Fino N, Leroy C.2002.A process for the preparation of 2-butyl [methanesulfonamido] benzofuran as an intermediate for the synthesis of dronedarone.WO 2002048132. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 50823 | 2-butyl-5-nitro-1-benzofuran | C12H13NO3 | 详情 | 详情 | |
| (II) | 67113 | 2-butylbenzofuran-6-amine | C12H15NO | 详情 | 详情 | |
| (III) | 67112 | N-(2-butylbenzofuran-6-yl)methanesulfonamide | C13H17NO3S | 详情 | 详情 | |
| (IV) | 10251 | methyl 4-hydroxybenzoate; Methyl p-hydroxybenzoate | 99-76-3 | C8H8O3 | 详情 | 详情 |
| (V) | 50826 | N,N-dibutyl-N-(3-chloropropyl)amine; N-butyl-N-(3-chloropropyl)-1-butanamine | 36421-15-5 | C11H24ClN | 详情 | 详情 |
| (VI) | 67114 | methyl 4-(3-(dibutylamino)propoxy)benzoate | 36421-15-5 | C19H31NO3 | 详情 | 详情 |
| (VII) | 67105 | 4-(3-(dibutylamino)propoxy)benzoyl chloride hydrochloride | C18H28ClNO2.HCl | 详情 | 详情 |
Extended Information