4-nitrobenzyl 4-mercapto-2-((sulfamoylamino)methyl)pyrrolidine-1-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】67099

【品名】4-nitrobenzyl 4-mercapto-2-((sulfamoylamino)methyl)pyrrolidine-1-carboxylate

【CA登记号】　　

【分子式】C₁₃H₁₈N₄O₆S₂

【分子量】390.441

【元素组成】C 39.99% H 4.65% N 14.35% O 24.59% S 16.43%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(II)

【1】 Tewari N, Meeran HNPN, Rai BP, et al. 2006. Aprocess for the preparation of doripenem. WO 2006117763 A2.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	16075	4-methoxybenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate	C₃₀H₃₀NO₉P	详情	详情
(II)	67099	4-nitrobenzyl 4-mercapto-2-((sulfamoylamino)methyl)pyrrolidine-1-carboxylate	C₁₃H₁₈N₄O₆S₂	详情	详情
(III)	67098	nitro(phenyl)methyl 6-(1-hydroxyethyl)-4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-(((((4-nitrobenzyl)oxy)carbonyl)(sulfamoyl)amino)methyl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate	C₃₈H₃₉N₇O₁₆S₂	详情	详情

该中间体在本合成路线中的序号：(IV)

【1】 Kanamoto K.2007. Process for producing carbapenem derivatives through reactions without isolating intermediates. WO 2007020960 A1.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	67100	4-nitrobenzyl 2-diazo-4-(3-(1-hydroxyethyl)-4-oxoazetidin-2-yl)-3-oxopentanoate	C₁₇H₁₈N₄O₇	详情	详情
(II)	37720	4-nitrobenzyl (4R,5R,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate	C₁₇H₁₈N₂O₇	详情	详情
(III)	16075	4-methoxybenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate	C₃₀H₃₀NO₉P	详情	详情
(IV)	67099	4-nitrobenzyl 4-mercapto-2-((sulfamoylamino)methyl)pyrrolidine-1-carboxylate	C₁₃H₁₈N₄O₆S₂	详情	详情
(V)	67098	nitro(phenyl)methyl 6-(1-hydroxyethyl)-4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-(((((4-nitrobenzyl)oxy)carbonyl)(sulfamoyl)amino)methyl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate	C₃₈H₃₉N₇O₁₆S₂	详情	详情

Extended Information