nitro(phenyl)methyl 4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】67092

【品名】nitro(phenyl)methyl 4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

【CA登记号】　

【分子式】C₃₃H₄₂N₆O₁₂S₂Si

【分子量】806.947

【元素组成】C 49.12% H 5.25% N 10.41% O 23.79% S 7.95% Si 3.48%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

参考文献中间体

合成目标

【1】 Liu K, Gao XS. Li Y, et al.2009. Process for preparation of doripenem. CN 101348485.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	67091	4-methoxybenzyl 3-((3-(aminomethyl)-4-(((4-nitrobenzyl)oxy)carbonyl)cyclopentyl)thio)-4-methyl-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₅H₄₅N₃O₉SSi	详情	详情
(II)	40598	amidosulfonoyl chloride	7778-42-9	H₂ClNO₂S	详情	详情
(III)	67092	nitro(phenyl)methyl 4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₃H₄₂N₆O₁₂S₂Si	详情	详情
(IV)	67081	nitro(phenyl)methyl 6-(1-hydroxyethyl)-4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₀H₃₄N₆O₁₂S₂	详情	详情
(V)	67085	4-nitrobenzyl 6-(1-hydroxyethyl)-4-methyl-7-oxo-3-((5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₂₂H₂₉N₅O₈S₂	详情	详情

Extended Information