4-nitrobenzyl 3-((5-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidin-3-yl)thio)-4-methyl-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】67089

【品名】4-nitrobenzyl 3-((5-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidin-3-yl)thio)-4-methyl-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

【CA登记号】　

【分子式】C₃₈H₅₀N₆O₁₄S₂Si

【分子量】907.065

【元素组成】C 50.32% H 5.56% N 9.27% O 24.69% S 7.07% Si 3.10%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

参考文献中间体

合成目标

【1】 Tang ZJ, Zhang QW, Shi HL.2007.Preparation of pyrrolidinothiocarbapenem derivative and intermediate. CN 101007806.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	16075	4-methoxybenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₀H₃₀NO₉P	详情	详情
(II)	67086	4-nitrobenzyl 3-((diphenoxyphosphoryl)oxy)-4-methyl-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₂H₃₅N₂O₁₀PSi	详情	详情
(III)	67087	4-nitrobenzyl 2-(hydroxymethyl)-4-mercaptopyrrolidine-1-carboxylate		C₁₃H₁₆N₂O₅S	详情	详情
(IV)	67088	4-nitrobenzyl 3-((5-(hydroxymethyl)-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidin-3-yl)thio)-4-methyl-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₃H₄₀N₄O₁₁SSi	详情	详情
(V)	16097	tert-butyl 2,2-dioxo-2lambda(6)-diazathiane-1-carboxylate	148017-28-1	C₅H₁₂N₂O₄S	详情	详情
(VI)	67089	4-nitrobenzyl 3-((5-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidin-3-yl)thio)-4-methyl-7-oxo-6-(1-((trimethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₈H₅₀N₆O₁₄S₂Si	详情	详情
(VII)	67090	4-nitrobenzyl 3-((5-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidin-3-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₅H₄₂N₆O₁₄S₂	详情	详情
(VIII)	67081	nitro(phenyl)methyl 6-(1-hydroxyethyl)-4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₀H₃₄N₆O₁₂S₂	详情	详情
(IX)	67085	4-nitrobenzyl 6-(1-hydroxyethyl)-4-methyl-7-oxo-3-((5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₂₂H₂₉N₅O₈S₂	详情	详情

Extended Information