(4S)-1-tert-butyl 2-methyl 4-((methylsulfonyl)oxy)pyrrolidine-1,2-dicarboxylate -Drug Synthesis Database

【结构式】

【分子编号】67084

【品名】(4S)-1-tert-butyl 2-methyl 4-((methylsulfonyl)oxy)pyrrolidine-1,2-dicarboxylate

【CA登记号】　

【分子式】C₁₂H₂₁NO₇S

【分子量】323.36728

【元素组成】C 44.57% H 6.55% N 4.33% O 34.63% S 9.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号： (III)

参考文献中间体

合成目标

【1】 Zhang AY, Zhu XY, Yuan ZD.2006.Synthesis of doripenem. Chin J Pharmaceuticals, 37: 361～363

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(III)	67084	(4S)-1-tert-butyl 2-methyl 4-((methylsulfonyl)oxy)pyrrolidine-1,2-dicarboxylate	C₁₂H₂₁NO₇S	详情	详情
(I)	67082	(4S)-4-hydroxypyrrolidine-2-carboxylic acid	C₅H₉NO₃	详情	详情
(II)	67083	(4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride	C₆H₁₁NO₃.HCl	详情	详情
(IV)	16095	tert-butyl (2S,4R)-2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]tetrahydro-1H-pyrrole-1-carboxylate	C₁₁H₂₁NO₆S	详情	详情
(V)	16096	tert-butyl (2S,4S)-4-(acetylsulfanyl)-2-(hydroxymethyl)tetrahydro-1H-pyrrole-1-carboxylate	C₁₂H₂₁NO₄S	详情	详情
(VI)	16098	tert-butyl (2S,4S)-4-(acetylsulfanyl)-2-[[(aminosulfonyl)(tert-butoxycarbonyl)amino]methyl]tetrahydro-1H-pyrrole-1-carboxylate	C₁₇H₃₁N₃O₇S₂	详情	详情
(VII)	16099	tert-butyl (2S,4S)-2-[[(aminosulfonyl)(tert-butoxycarbonyl)amino]methyl]-4-sulfanyltetrahydro-1H-pyrrole-1-carboxylate	C₁₅H₂₉N₃O₆S₂	详情	详情
(VIII)	16100	benzhydryl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate	C₃₅H₃₂NO₈P	详情	详情
(IX)	16101	benzhydryl (4R,5S,6S)-3-[[(3S,5S)-5-[[(aminosulfonyl)(tert-butoxycarbonyl)amino]methyl]-1-(tert-butoxycarbonyl)pyrrolidinyl]sulfanyl]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate	C₃₈H₅₀N₄O₁₀S₂	详情	详情
(X)	67085	4-nitrobenzyl 6-(1-hydroxyethyl)-4-methyl-7-oxo-3-((5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate	C₂₂H₂₉N₅O₈S₂	详情	详情

Extended Information