【结 构 式】 |
【分子编号】67068 【品名】1-methyl 5-vinyl 2-acetyl-3-(2,3-dichlorophenyl)-4-(1-((1-phenylethyl)amino)ethylidene)pentanedioate 【CA登记号】 |
【 分 子 式 】C27H29Cl2NO5 【 分 子 量 】518.436 【元素组成】C 62.55% H 5.64% Cl 13.68% N 2.70% O 15.43% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)
【1】 Andersson KH, Nordlander M, Westerlund RC, (AstraZeneca plc). Short-acting dihydropyridines. EP 0726894; JP 1997504542; US 5856346; WO 9512578. |
【2】 Kosugi Y, Hori M, Nagasaka T. 1994. Synthesis of optically pure 1,4-dihydropyridine derivatives by means od diastereoisomeric separation of the Hantzsch intermediates bearing (R) -1-phenylethylamino group. Heterocycles, 39(2) : 591~602. |
【3】 Mattson A, Svensson C, Thonblom K, et al. (AstraZeneca AB). New manufacturing process. CA 2349195; EP 1133473; US 6350877; WO 0031035. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 20790 | Methyl (Z)-2,3-dichlorobenzyldeneacetoacetate; Methyl (Z)-2-acetyl-3-(2,3-dichlorophenyl)-2-propenoate | 74073-22-6 | C12H10Cl2O3 | 详情 | 详情 |
(II) | 67067 | (Z)-allyl 3-((1-phenylethyl)amino)but-2-enoate | C15H19NO2 | 详情 | 详情 | |
(III) | 67068 | 1-methyl 5-vinyl 2-acetyl-3-(2,3-dichlorophenyl)-4-(1-((1-phenylethyl)amino)ethylidene)pentanedioate | C27H29Cl2NO5 | 详情 | 详情 | |
(IV) | 67069 | 3-allyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | C19H19Cl2NO4 | 详情 | 详情 | |
(V) | 17945 | 4-(2,3-dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid | 105580-45-8 | C16H15Cl2NO4 | 详情 | 详情 |
(VI) | 17946 | chloromethyl butyrate | 33657-49-7 | C5H9ClO2 | 详情 | 详情 |
Extended Information