(R,Z)-5-methyl-6-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)cyclohex-1-enecarbaldehyde -Drug Synthesis Database

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【结构式】

【分子编号】67039

【品名】(R,Z)-5-methyl-6-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)cyclohex-1-enecarbaldehyde

【CA登记号】　

【分子式】C₁₇H₂₆O₃

【分子量】278.39164

【元素组成】C 73.35% H 9.41% O 17.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

合成路线1

该中间体在本合成路线中的序号：(IX)

　

参考文献中间体

【1】 Avery MA, Chong WKM, Jennings-White C. 1992. Stereoselective total synthesis of (+) -artemisinin, the antimalarial constitutent of Artemisia annua L. J Am Chem Soc, 114(3): 974～979.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	67032	(6R)-2,2,6-trimethyl-1-oxaspiro[2.5]octan-4-one		C₁₀H₁₆O₂	详情	详情
(I)	56751	(5R)-5-methyl-2-(1-methylethylidene)cyclohexanone		C₁₀H₁₆O	详情	详情
(III)	67033	(5S)-5-methyl-2-(phenylthio)cyclohexanone		C₁₃H₁₆OS	详情	详情
(IV)	67034	(5R)-5-methyl-2-(phenylsulfinyl)cyclohexanone		C₁₃H₁₆O₂S	详情	详情
(V)	67035	2-(2-bromoethyl)-2,5,5-trimethyl-1,3-dioxane	87842-52-2	C₉H₁₇BrO₂	详情	详情
(VI)	67036	(3R,Z)-3-methyl-6-(phenylsulfinyl)-2-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)cyclohexanone		C₂₂H₃₀O₄S	详情	详情
(VII)	67037	(R,Z)-3-methyl-2-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)cyclohexanone		C₁₆H₂₆O₃	详情	详情
(VIII)	67038	(Z)-4-methyl-N'-((R,Z)-3-methyl-2-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)cyclohexylidene)benzenesulfonohydrazide		C₂₃H₃₄N₂O₄S	详情	详情
(IX)	67039	(R,Z)-5-methyl-6-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)cyclohex-1-enecarbaldehyde		C₁₇H₂₆O₃	详情	详情
(X)	67040	((R,Z)-5-methyl-6-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)cyclohex-1-en-1-yl)(trimethylsilyl)methyl acetate		C₂₂H₃₈O₄Si	详情	详情
(XI)	67041	2-((2Z,3Z,4R)-4-methyl-3-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)-2-((trimethylsilyl)methylene)cyclohexyl)acetic acid		C₂₂H₃₈O₄Si	详情	详情
(XII)	67042	2-((1R,2Z,3Z,4S)-4-methyl-3-(2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethylidene)-2-((trimethylsilyl)methylene)cyclohexyl)propanoic acid		C₂₃H₄₀O₄Si	详情	详情

Extended Information