benzyl 2-(2-benzyl-3-(4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetate -Drug Synthesis Database

【结构式】

【分子编号】67027

【品名】benzyl 2-(2-benzyl-3-(4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetate

【CA登记号】　

【分子式】C₃₂H₃₈N₂O₄

【分子量】514.6648

【元素组成】C 74.68% H 7.44% N 5.44% O 12.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XV)

参考文献中间体

合成目标

【1】 Li L, Tian QS, Wei WT, et al. 2003. Process for preparation of alvimopan and intermediates. 发明专利申请公开说明书， CN 1827598(Tianjiu Taipu Medicine Science and Technology Development Co, Ltd, Peop Rep China)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	16618	(3R,4R)-4-(3-isopropoxyphenyl)-1,3,4-trimethylhexahydropyridine; isopropyl 3-[(3R,4R)-1,3,4-trimethylhexahydro-4-pyridinyl]phenyl ether		C₁₇H₂₇NO	详情	详情
(II)	67026	(3R,4R)-phenyl 4-(3-isopropoxyphenyl)-3,4-dimethylpiperidine-1-carboxylate		C₂₃H₂₉NO₃	详情	详情
(III)	16620	3-[(3R,4R)-3,4-dimethylhexahydro-4-pyridinyl]phenol	119193-19-0	C₁₃H₁₉NO	详情	详情
(IV)	10498	Benzaldehyde;Benzoic aldehyde;Phenylmethanal	100-52-7	C₇H₆O	详情	详情
(V)	14156	methyl acrylate	96-33-3	C₄H₆O₂	详情	详情
(VI)	49470	methyl 2-[hydroxy(phenyl)methyl]acrylate		C₁₁H₁₂O₃	详情	详情
(VII)	49475	methyl (E)-2-[(acetoxy)methyl]-3-phenyl-2-propenoate		C₁₃H₁₄O₄	详情	详情
(VIII)	49476	(E)-2-(hydroxymethyl)-3-phenyl-2-propenoic acid		C₁₀H₁₀O₃	详情	详情
(IX)	49480	2-benzyl-3-hydroxypropionic acid		C₁₀H₁₂O₃	详情	详情
(X)	49481	(2S)-2-benzyl-3-hydroxypropionic acid		C₁₀H₁₂O₃	详情	详情
(XI)	13601	benzyl 2-aminoacetate; Glycine benzyl ester hydrochloride	1738-68-7	C₉H₁₁NO₂	详情	详情
(XII)	49477	benzyl 2-[[(2S)-2-benzyl-3-hydroxypropanoyl]amino]acetate		C₁₉H₂₁NO₄	详情	详情
(XIII)	49478	benzyl 2-([(2S)-2-benzyl-3-[(methylsulfonyl)oxy]propanoyl]amino)acetate		C₂₀H₂₃NO₆S	详情	详情
(XIV)	49479	benzyl 2-[[(2S)-2-benzyl-3-bromopropanoyl]amino]acetate		C₁₉H₂₀BrNO₃	详情	详情
(XV)	67027	benzyl 2-(2-benzyl-3-(4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetate		C₃₂H₃₈N₂O₄	详情	详情

Extended Information