【结 构 式】 |
【分子编号】67023 【品名】(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyltetrahydro-1(2H)-pyridiniumyl]propanoate 【CA登记号】 |
【 分 子 式 】C23H29NO3 【 分 子 量 】367.4882 【元素组成】C 75.17% H 7.95% N 3.81% O 13.06% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XI)
【1】 Buehler JD. 2007. Process for preparing alvimopan and their compositions containing opioid antagonists. WO 2007047935(Adolor Corp., USA). |
【2】 Copley-Merriman CR, Maki J, Barnett CJ. 1989. Synthesis of picenadol via metalloenamine alkylation methodology. J Org Chem, 54(4): 795~800. |
【3】 Frank SA, Prather DE, Ward JA, et al. 1995. Preparation of 3,4,4-trisubtituted piperidinyl N-alkylcarboxylates and intermediates, useful as opioid antagonists. EP 657428(Eli Lilly and Co., USA) |
【4】 Robey RL, Evans DA, Zimmerman DM, et al. 1980. Application of metalated enamines to alkaloid synthesis. An expedient approach to the synthesis of morphine-based analgesics. J Am Chem Soc, 102(5): 955~956 |
【5】 Werner JA, Cerbone LR, Frank SA, et al. 1996. Synthesis of trans-3,4-dimethyl-(3-hydroxyphenyl)piperidine opioid antagonists: application of the cis-thermal elimination of carbonates to alkaloid synthesis. J Org Chem, 61(2):587~597 |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(X) | 16621 | (3R,4R)-1-[(2S)-2-benzyl-3-methoxy-3-oxopropyl]-4-(3-hydroxyphenyl)-3,4-dimethylhexahydropyridinium chloride | C24H32ClNO3 | 详情 | 详情 | |
(I) | 16614 | 1,3-dimethyltetrahydro-4(1H)-pyridinone; 1,3-Dimethyl-4-piperidone | 4629-80-5 | C7H13NO | 详情 | 详情 |
(II) | 66993 | (3-isopropoxyphenyl)lithium | C9H11LiO | 详情 | 详情 | |
(III) | 16615 | (3S,4R)-4-(3-isopropoxyphenyl)-1,3-dimethylhexahydro-4-pyridinol | C16H25NO2 | 详情 | 详情 | |
(IV) | 16616 | ethyl (3S,4R)-4-(3-isopropoxyphenyl)-1,3-dimethylhexahydro-4-pyridinyl carbonate | C19H29NO4 | 详情 | 详情 | |
(V) | 16617 | (3R)-4-(3-isopropoxyphenyl)-1,3-dimethyl-1,2,3,6-tetrahydropyridine; 3-[(3R)-1,3-dimethyl-1,2,3,6-tetrahydro-4-pyridinyl]phenyl isopropyl ether | C16H23NO | 详情 | 详情 | |
(VI) | 67021 | C17H25NO | 详情 | 详情 | ||
(VII) | 16618 | (3R,4R)-4-(3-isopropoxyphenyl)-1,3,4-trimethylhexahydropyridine; isopropyl 3-[(3R,4R)-1,3,4-trimethylhexahydro-4-pyridinyl]phenyl ether | C17H27NO | 详情 | 详情 | |
(VIII) | 16620 | 3-[(3R,4R)-3,4-dimethylhexahydro-4-pyridinyl]phenol | 119193-19-0 | C13H19NO | 详情 | 详情 |
(IX) | 67022 | methyl 3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate | C17H25NO3 | 详情 | 详情 | |
(XI) | 67023 | (2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyltetrahydro-1(2H)-pyridiniumyl]propanoate | C23H29NO3 | 详情 | 详情 | |
(XII) | 67024 | tert-butyl 2-(2-benzyl-3-(4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetate | C29H40N2O4 | 详情 | 详情 | |
(XIII) | 67025 | 2-([(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic acid | C25H32N2O4 | 详情 | 详情 |
Extended Information