benzyl (2S,4R)-4-isopropyl-5-oxotetrahydro-2-furancarboxylate -Drug Synthesis Database

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【结构式】

【分子编号】67008

【品名】benzyl (2S,4R)-4-isopropyl-5-oxotetrahydro-2-furancarboxylate

【CA登记号】　

【分子式】C₁₅H₁₈O₄

【分子量】262.30552

【元素组成】C 68.69% H 6.92% O 24.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

合成路线1

该中间体在本合成路线中的序号：(V)

　

参考文献中间体

【1】 Rueger H, Stutz S, Goschke R, et al. 2000. A convergent synthesisi approach towards CGP60536B, a nonpeptide orally potent renin inhibitory, via an enantiomerically pure keto lactone intermediate. Tetrahedron Lett, 41(51): 10085～10089

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28131	(4S)-4-benzyl-3-(3-methylbutanoyl)-1,3-oxazolidin-2-one		C₁₅H₁₉NO₃	详情	详情
(II)	50566	(4S)-4-benzyl-3-[(2S)-2-isopropyl-4-pentenoyl]-1,3-oxazolidin-2-one		C₁₈H₂₃NO₃	详情	详情
(III)	50567	(3S)-5-(hydroxymethyl)-3-isopropyldihydro-2(3H)-furanone		C₈H₁₄O₃	详情	详情
(IV)	50569	(4S)-4-isopropyl-5-oxotetrahydro-2-furancarbonyl chloride		C₈H₁₁ClO₃	详情	详情
(V)	67008	benzyl (2S,4R)-4-isopropyl-5-oxotetrahydro-2-furancarboxylate		C₁₅H₁₈O₄	详情	详情
(VI)	50570	benzyl (2S,4S)-4-isopropyl-5-oxotetrahydro-2-furancarboxylate		C₁₅H₁₈O₄	详情	详情
(VII)	50571	(2S,4S)-4-isopropyl-5-oxotetrahydro-2-furancarboxylic acid		C₈H₁₂O₄	详情	详情
(VIII)	50572	(2S,4S)-4-isopropyl-5-oxotetrahydro-2-furancarbonyl chloride		C₈H₁₁ClO₃	详情	详情
(IX)	28119	(2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyric acid		C₁₇H₂₆O₅	详情	详情
(X)	50573	(2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methyl-1-butanol		C₁₇H₂₈O₄	详情	详情
(XI)	50574	4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene; 3-[5-[(2R)-2-(chloromethyl)-3-methylbutyl]-2-methoxyphenoxy]propyl methyl ether	324763-39-5	C₁₇H₂₇ClO₃	详情	详情
(XII)	50575	(3S,5S)-3-isopropyl-5-[(3S)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentanoyl]dihydro-2(3H)-furanone		C₂₅H₃₈O₆	详情	详情
(XIII)	50576	(3S,5S)-5-[(1R,3S)-1-hydroxy-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]-3-isopropyldihydro-2(3H)-furanone		C₂₅H₄₀O₆	详情	详情
(XIV)	50578	(3S,5S)-5-[(1S,3S)-1-azido-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]-3-isopropyldihydro-2(3H)-furanone		C₂₅H₃₉N₃O₅	详情	详情
(XV)	28129	3-amino-2,2-dimethylpropanamide	324763-51-1	C₅H₁₂N₂O	详情	详情
(XVI)	50579	(2S,4S,5S,7S)-N-(4-amino-2,2-dimethyl-4-oxobutyl)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide		C₃₁H₅₃N₅O₆	详情	详情

Extended Information