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【结 构 式】 
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【分子编号】67008 【品名】benzyl (2S,4R)-4-isopropyl-5-oxotetrahydro-2-furancarboxylate 【CA登记号】 |
【 分 子 式 】C15H18O4 【 分 子 量 】262.30552 【元素组成】C 68.69% H 6.92% O 24.4% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)
| 【1】 Rueger H, Stutz S, Goschke R, et al. 2000. A convergent synthesisi approach towards CGP60536B, a nonpeptide orally potent renin inhibitory, via an enantiomerically pure keto lactone intermediate. Tetrahedron Lett, 41(51): 10085～10089 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28131 | (4S)-4-benzyl-3-(3-methylbutanoyl)-1,3-oxazolidin-2-one | C15H19NO3 | 详情 | 详情 | |
| (II) | 50566 | (4S)-4-benzyl-3-[(2S)-2-isopropyl-4-pentenoyl]-1,3-oxazolidin-2-one | C18H23NO3 | 详情 | 详情 | |
| (III) | 50567 | (3S)-5-(hydroxymethyl)-3-isopropyldihydro-2(3H)-furanone | C8H14O3 | 详情 | 详情 | |
| (IV) | 50569 | (4S)-4-isopropyl-5-oxotetrahydro-2-furancarbonyl chloride | C8H11ClO3 | 详情 | 详情 | |
| (V) | 67008 | benzyl (2S,4R)-4-isopropyl-5-oxotetrahydro-2-furancarboxylate | C15H18O4 | 详情 | 详情 | |
| (VI) | 50570 | benzyl (2S,4S)-4-isopropyl-5-oxotetrahydro-2-furancarboxylate | C15H18O4 | 详情 | 详情 | |
| (VII) | 50571 | (2S,4S)-4-isopropyl-5-oxotetrahydro-2-furancarboxylic acid | C8H12O4 | 详情 | 详情 | |
| (VIII) | 50572 | (2S,4S)-4-isopropyl-5-oxotetrahydro-2-furancarbonyl chloride | C8H11ClO3 | 详情 | 详情 | |
| (IX) | 28119 | (2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyric acid | C17H26O5 | 详情 | 详情 | |
| (X) | 50573 | (2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methyl-1-butanol | C17H28O4 | 详情 | 详情 | |
| (XI) | 50574 | 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene; 3-[5-[(2R)-2-(chloromethyl)-3-methylbutyl]-2-methoxyphenoxy]propyl methyl ether | 324763-39-5 | C17H27ClO3 | 详情 | 详情 |
| (XII) | 50575 | (3S,5S)-3-isopropyl-5-[(3S)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentanoyl]dihydro-2(3H)-furanone | C25H38O6 | 详情 | 详情 | |
| (XIII) | 50576 | (3S,5S)-5-[(1R,3S)-1-hydroxy-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]-3-isopropyldihydro-2(3H)-furanone | C25H40O6 | 详情 | 详情 | |
| (XIV) | 50578 | (3S,5S)-5-[(1S,3S)-1-azido-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]-3-isopropyldihydro-2(3H)-furanone | C25H39N3O5 | 详情 | 详情 | |
| (XV) | 28129 | 3-amino-2,2-dimethylpropanamide | 324763-51-1 | C5H12N2O | 详情 | 详情 |
| (XVI) | 50579 | (2S,4S,5S,7S)-N-(4-amino-2,2-dimethyl-4-oxobutyl)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide | C31H53N5O6 | 详情 | 详情 |
Extended Information