N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-(benzylamino)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide -Drug Synthesis Database

【结构式】

【分子编号】67007

【品名】N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-(benzylamino)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

【CA登记号】　

【分子式】C₃₇H₅₉N₃O₆

【分子量】641.89208

【元素组成】C 69.23% H 9.26% N 6.55% O 14.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

参考文献中间体

合成目标

【1】 Dondoni A, De Lathauwer G. 2001. A convergent synthesisi of the renin inhibitor SPP-100 using a nitrone intermediate. Tetrahedron Lett. 42(29): 4819～4823

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(R-5)	50594	N-benzyl-N-[(3S)-1-[(2S,3S,5R,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-azaspiro[4.4]non-7-yl]-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]hydroxylamine; (2S,3S,5R,7S,9S)-7-[(3S)-1-[benzyl(hydroxy)amino]-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-azaspiro[4.4]nonane		C₄₂H₆₀N₂O₆	详情	详情
(I)	50588	[(2S,3S,5R,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-azaspiro[4.4]non-7-yl]methanol		C₁₈H₂₇NO₃	详情	详情
(II)	50589	(2S,3S,5R,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-azaspiro[4.4]nonane-7-carbaldehyde		C₁₈H₂₅NO₃	详情	详情
(III)	50597	benzyl[(E)-[(2S,3S,5R,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-azaspiro[4.4]non-7-yl]methylidene]ammoniumolate		C₂₅H₃₂N₂O₃	详情	详情
(IV)	50574	4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene; 3-[5-[(2R)-2-(chloromethyl)-3-methylbutyl]-2-methoxyphenoxy]propyl methyl ether	324763-39-5	C₁₇H₂₇ClO₃	详情	详情
(VI)	67006	5-(1-(benzyl(hydroxy)amino)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one		C₃₂H₄₇NO₆	详情	详情
(VII)	28129	3-amino-2,2-dimethylpropanamide	324763-51-1	C₅H₁₂N₂O	详情	详情
(VIII)	67007	N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-(benzylamino)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide		C₃₇H₅₉N₃O₆	详情	详情

Extended Information