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【结 构 式】

【分子编号】66994

【品名】tert-butyl (8-((3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate

【CA登记号】 

【 分 子 式 】C35H61N3O8

【 分 子 量 】651.885

【元素组成】C 64.49% H 9.43% N 6.45% O 19.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(X)

 

1 Maibaum J, Stutz S, Goschke R, et al. 2007. Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydro-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets. J Med Chem, 50(20): 4832~4844
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 66991 (R)-((2-(bromomethyl)-3-methylbutoxy)methyl)benzene   C13H19BrO 详情 详情
(V) 66992     C40H63NO7 详情 详情
(VIII) 28129 3-amino-2,2-dimethylpropanamide 324763-51-1 C5H12N2O 详情 详情
(I) 28123 tert-butyl (1S,3S)-1-formyl-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentylcarbamate C24H39NO6 详情 详情
(III) 28125 tert-butyl (1S,4S)-4-[(benzyloxy)methyl]-2-hydroxy-1-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-5-methylhexylcarbamate C37H59NO7 详情 详情
(IV) 10722 1-Methoxy-1-methylethyl methyl ether; 2,2-Dimethoxypropane 77-76-9 C5H12O2 详情 详情
(VI) 28127 tert-butyl (4S,5S)-5-[(2S)-2-(hydroxymethyl)-3-methylbutyl]-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate C33H57NO7 详情 详情
(VII) 28128 (2S)-2-[((4S,5S)-3-(tert-butoxycarbonyl)-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidin-5-yl)methyl]-3-methylbutyric acid C33H55NO8 详情 详情
(IX) 28130 tert-butyl (4S,5S)-5-((2S)-2-[[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl]-3-methylbutyl)-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate C38H65N3O8 详情 详情
(X) 66994 tert-butyl (8-((3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate   C35H61N3O8 详情 详情
(XII) 28126 tert-butyl (4S,5S)-5-[(2S)-2-[(benzyloxy)methyl]-3-methylbutyl]-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate C40H63NO7 详情 详情
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