tert-butyl (8-((3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate -Drug Synthesis Database

【结构式】

【分子编号】66994

【品名】tert-butyl (8-((3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate

【CA登记号】　

【分子式】C₃₅H₆₁N₃O₈

【分子量】651.885

【元素组成】C 64.49% H 9.43% N 6.45% O 19.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

参考文献中间体

合成目标

【1】 Maibaum J, Stutz S, Goschke R, et al. 2007. Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydro-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets. J Med Chem, 50(20): 4832～4844

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	66991	(R)-((2-(bromomethyl)-3-methylbutoxy)methyl)benzene		C₁₃H₁₉BrO	详情	详情
(V)	66992			C₄₀H₆₃NO₇	详情	详情
(VIII)	28129	3-amino-2,2-dimethylpropanamide	324763-51-1	C₅H₁₂N₂O	详情	详情
(I)	28123	tert-butyl (1S,3S)-1-formyl-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentylcarbamate		C₂₄H₃₉NO₆	详情	详情
(III)	28125	tert-butyl (1S,4S)-4-[(benzyloxy)methyl]-2-hydroxy-1-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-5-methylhexylcarbamate		C₃₇H₅₉NO₇	详情	详情
(IV)	10722	1-Methoxy-1-methylethyl methyl ether; 2,2-Dimethoxypropane	77-76-9	C₅H₁₂O₂	详情	详情
(VI)	28127	tert-butyl (4S,5S)-5-[(2S)-2-(hydroxymethyl)-3-methylbutyl]-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate		C₃₃H₅₇NO₇	详情	详情
(VII)	28128	(2S)-2-[((4S,5S)-3-(tert-butoxycarbonyl)-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidin-5-yl)methyl]-3-methylbutyric acid		C₃₃H₅₅NO₈	详情	详情
(IX)	28130	tert-butyl (4S,5S)-5-((2S)-2-[[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl]-3-methylbutyl)-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate		C₃₈H₆₅N₃O₈	详情	详情
(X)	66994	tert-butyl (8-((3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate		C₃₅H₆₁N₃O₈	详情	详情
(XII)	28126	tert-butyl (4S,5S)-5-[(2S)-2-[(benzyloxy)methyl]-3-methylbutyl]-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate		C₄₀H₆₃NO₇	详情	详情

Extended Information