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【结 构 式】 
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【分子编号】66890 【品名】2-(3-((tert-butyldimethylsilyl)oxy)benzyl)-1-((N-methylphenylsulfonimidoyl)methyl)-4-((tetrahydro-2H-pyran-2-yl)peroxy)-3-(3-((tetrahydro-2H-pyran-2-yl)peroxy)octyl)cyclopentanol 【CA登记号】 |
【 分 子 式 】C44H71NO9SSi 【 分 子 量 】818.201 【元素组成】C 64.59% H 8.75% N 1.71% O 17.60% S 3.92% Si 3.42% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)
| 【1】 Aristoff PA. 1987. Interphenylene carbacyclin derivatives. US 4683330(本专利属于The Upjohn Compa- ny) Aristoff PA 1981．Composition and pro卧US 4306075(本专利■于The Upjohn Company) Aristoff PA. 1982，Methno carbacyclin analogs US 4349689(本专利属于The Upjohn Company) |
| 【2】 Aristoff PA. 1981．Composition and process. US 4306075(本专利属于The Upjohn Company) |
| 【3】 Aristoff PA. 1982. Methno carbacyclin analogs. US 4349689(本专利属于The Upjohn Company) |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14647 | 5-methoxy-3,4-dihydro-2(1H)-naphthalenone | 32940-15-1 | C11H12O2 | 详情 | 详情 |
| (II) | 46567 | (3aS)-5-methoxy-3a,4-dihydronaphtho[2,3-b]furan-2(3H)-one | C13H12O3 | 详情 | 详情 | |
| (III) | 46566 | dimethyl (4S)-4-(tetrahydro-2H-pyran-2-yloxy)nonylphosphonate | C16H33O5P | 详情 | 详情 | |
| (IV) | 46568 | (9aS)-8-methoxy-3-[(3S)-3-(tetrahydro-2H-pyran-2-yloxy)octyl]-1,4,9,9a-tetrahydro-2H-cyclopenta[b]naphthalen-2-one | C27H38O4 | 详情 | 详情 | |
| (VI) | 46549 | (2R,3R,4R)-2-(3-[[tert-butyl(dimethyl)silyl]oxy]benzyl)-4-(tetrahydro-2H-pyran-2-yloxy)-3-[(E,3S)-3-(tetrahydro-2H-pyran-2-yloxy)-1-octenyl]cyclopentanone | C36H58O6Si | 详情 | 详情 | |
| (VII) | 66890 | 2-(3-((tert-butyldimethylsilyl)oxy)benzyl)-1-((N-methylphenylsulfonimidoyl)methyl)-4-((tetrahydro-2H-pyran-2-yl)peroxy)-3-(3-((tetrahydro-2H-pyran-2-yl)peroxy)octyl)cyclopentanol | C44H71NO9SSi | 详情 | 详情 | |
| (VIII) | 46555 | [(1S,2S,3S,4R)-2-(3-hydroxybenzyl)-4-(tetrahydro-2H-pyran-2-yloxy)-3-[(E,3S)-3-(tetrahydro-2H-pyran-2-yloxy)-1-octenyl]cyclopentyl]methyl methanesulfonate | C32H50O8S | 详情 | 详情 | |
| (IX) | 46556 | (1S,2R,3aS,9aS)-2-(tetrahydro-2H-pyran-2-yloxy)-1-[(E,3S)-3-(tetrahydro-2H-pyran-2-yloxy)-1-octenyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-ol | C31H46O5 | 详情 | 详情 |
Extended Information