dimethyl 2-oxo-3-[3-(trifluoromethyl)phenoxy]propylphosphonate -Drug Synthesis Database

Current Location： Home > Feedback Help Print

【结构式】

【分子编号】66880

【品名】dimethyl 2-oxo-3-[3-(trifluoromethyl)phenoxy]propylphosphonate

【CA登记号】　

【分子式】C₁₂H₁₆F₃O₅P

【分子量】328.225

【元素组成】C 43.91% H 4.91% F 17.36% O 24.37% P 9.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

合成路线1

该中间体在本合成路线中的序号：(IV)

　

参考文献中间体

【1】 Selliah R, Dantanarayana A, Haggard K, et al. 2001. Synthesis of [phenyl-2-3H]-travoprost; isopropyl ester prodrug of a selective prostaglandin FP receptor agonist. J Label Comp Radiopharm, 44(3): 173～183

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	52922	2-iodo-5-(trifluoromethyl)phenol		C₇H₄F₃IO	详情	详情
(II)	52923	ethyl 2-[2-iodo-5-(trifluoromethyl)phenoxy]acetate	n/a	C₁₁H₁₀F₃IO₃	详情	详情
(III)	52924	dimethyl 3-[2-iodo-5-(trifluoromethyl)phenoxy]-2-oxopropylphosphonate		C₁₂H₁₃F₃IO₅P	详情	详情
(IV)	66880	dimethyl 2-oxo-3-[3-(trifluoromethyl)phenoxy]propylphosphonate		C₁₂H₁₆F₃O₅P	详情	详情
(V)	33585	(8R,9S,10R,13S,14S)-13-ethyl-11-methylene-3-(1-pyrrolidinyl)-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydro-17H-cyclopenta[a]phenanthren-17-one		C₂₄H₃₃NO	详情	详情
(VI)	52925	(3aR,4R,5R,6aS)-4-{(E)-4-[2-iodo-5-(trifluoromethyl)phenoxy]-3-oxo-1-butenyl}-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate		C₂₅H₂₀F₃IO₆	详情	详情
(VII)	52926	(3aR,4R,5R,6aS)-4-{(E)-3-hydroxy-4-[2-iodo-5-(trifluoromethyl)phenoxy]-1-butenyl}-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate		C₂₅H₂₂F₃IO₆	详情	详情
(VIII)	52927	(3aR,4R,5R,6aS)-5-hydroxy-4-{(E)-3-hydroxy-4-[2-iodo-5-(trifluoromethyl)phenoxy]-1-butenyl}hexahydro-2H-cyclopenta[b]furan-2-one		C₁₈H₁₈F₃IO₅	详情	详情
(IX)	52928	(3aR,4R,5R,6aS)-4-[(E)-4-[2-iodo-5-(trifluoromethyl)phenoxy]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one		C₂₈H₃₄F₃IO₇	详情	详情
(X)	52929	(3aR,4R,5R,6aS)-4-[(E)-4-[2-iodo-5-(trifluoromethyl)phenoxy]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-ol		C₂₈H₃₆F₃IO₇	详情	详情
(XI)	52930	(Z)-7-[(1R,2R,3R,5S)-5-hydroxy-2-[(E)-4-[2-iodo-5-(trifluoromethyl)phenoxy]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]-5-heptenoic acid		C₃₃H₄₄F₃IO₈	详情	详情
(XII)	52932	isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(E,3R)-3-hydroxy-4-[2-iodo-5-(trifluoromethyl)phenoxy]-1-butenyl}cyclopentyl)-5-heptenoate		C₂₆H₃₄F₃IO₆	详情	详情

Extended Information