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【结 构 式】 
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【分子编号】66848 【品名】(4S,4aS,5aR,12aS)-2-(chloromethyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydro-1H-cyclopenta[a]tetracene-10-carboxamide 【CA登记号】 |
【 分 子 式 】C27H30ClN3O6 【 分 子 量 】528.005 【元素组成】C 61.42% H 5.73% Cl 6.71% N 7.96% O 18.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)
| 【1】 Sum PE, How DB, Hopper DW, et al. 2005. Preparation of oxazole derivatives of tetracyclines as antibacterial agents. W0 2005056538 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 65813 | Minocycline hydrochloride; [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride | 13614-98-7 | C23H27N3O7.HCl | 详情 | 详情 |
| (II) | 66844 | (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-nitro-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide monosulfate | C23H26N4O9.2H2SO4 | 详情 | 详情 | |
| (III) | 66845 | (4S,4aS,5aR,12aS)-9-amino-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide monosulfate | C23H28N4O7.2H2SO4 | 详情 | 详情 | |
| (IV) | 66848 | (4S,4aS,5aR,12aS)-2-(chloromethyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydro-1H-cyclopenta[a]tetracene-10-carboxamide | C27H30ClN3O6 | 详情 | 详情 |
Extended Information