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【结 构 式】 
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【分子编号】66805 【品名】(2R,3R,4S)-6-(((3S,4R,6S,7S,9S,13R,14S)-6-(((2R,3S,4R,6S)-3-(benzoyloxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-13-hydroxy-7-methoxy-3,5,7,9,11,13-pentamethyl-2,10-dioxooxacyclotetradec-11-en-4-yl)oxy)-4-methoxy-2,4-dimethyltetrahydro-2H-pyran-3-yl benzoate 【CA登记号】 |
【 分 子 式 】C52H75NO14 【 分 子 量 】938.166 【元素组成】C 66.57% H 8.06% N 1.49% O 23.87% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)
| 【1】 Burger MT, Hiebert C，Seid M, et aL. 2006. Synthesis and antibacterial activity of novel C12 ethyl ketolides Bioorganic & Medicinal Chemistry, 14(16):5592～5604 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 66801 | (3S,4R,6S,7S,9S,11S,12S,13R,14S)-6-(((2R,3S,4R,6S)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-4-(((4S,5R,6R)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-3,5,7,9,11,13-pentamethyloxacyclotetradecane-2,10-dione | C38H69NO13 | 详情 | 详情 | |
| (II) | 66802 | (2R,3R,4S)-6-(((3S,4R,6S,7S,9S,11S,12S,13R,14S)-6-(((2R,3S,4R,6S)-3-(benzoyloxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-pentamethyl-2,10-dioxooxacyclotetradecan-4-yl)oxy)-4-methoxy-2,4-dimethyltetrahydro-2H-pyran-3-yl benzoate | C52H77NO15 | 详情 | 详情 | |
| (III) | 66803 | (2R,3R,4S)-6-(((3S,4R,6S,7S,9S,11S,12S,13S,14S)-6-(((2R,3S,4R,6S)-3-(benzoyloxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-13-hydroxy-7-methoxy-3,5,7,9,11,13-pentamethyl-12-((methylsulfonyl)oxy)-2,10-dioxooxacyclotetradecan-4-yl)oxy)-4-methoxy-2,4-dimethyltetrahydro-2H-pyran-3-yl benzoate | C53H79NO17S | 详情 | 详情 | |
| (IV) | 66805 | (2R,3R,4S)-6-(((3S,4R,6S,7S,9S,13R,14S)-6-(((2R,3S,4R,6S)-3-(benzoyloxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-13-hydroxy-7-methoxy-3,5,7,9,11,13-pentamethyl-2,10-dioxooxacyclotetradec-11-en-4-yl)oxy)-4-methoxy-2,4-dimethyltetrahydro-2H-pyran-3-yl benzoate | C52H75NO14 | 详情 | 详情 | |
| (V) | 66806 | (2R,3S,4R,6S)-4-(dimethylamino)-2-(((3S,4R,6S,7S,9S,13R,14S)-14-ethyl-4,13-dihydroxy-7-methoxy-3,5,7,9,11,13-pentamethyl-2,10-dioxooxacyclotetradec-11-en-6-yl)oxy)-6-methyltetrahydro-2H-pyran-3-yl benzoate | C37H57NO10 | 详情 | 详情 | |
| (VI) | 66807 | (2R,3S,4R,6S)-4-(dimethylamino)-2-(((3S,6S,7S,9S,13R,14S)-14-ethyl-13-hydroxy-7-methoxy-3,5,7,9,11,13-pentamethyl-2,4,10-trioxooxacyclotetradec-11-en-6-yl)oxy)-6-methyltetrahydro-2H-pyran-3-yl benzoate | C37H56NO10 | 详情 | 详情 | |
| (VII) | 66808 | (2S,3R,7S,9S,10S,13S)-10-(((2R,3S,4R,6S)-3-(benzoyloxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-9-methoxy-3,5,7,9,11,13-pentamethyl-6,12,14-trioxooxacyclotetradec-4-en-3-yl 1H-imidazole-1-carboxylate | C41H58N3O11 | 详情 | 详情 | |
| (VIII) | 66809 | (2R,3S,4R,6S)-4-(dimethylamino)-2-(((3aR,4S,7S,10S,11S,13S,15S,15aS)-4-ethyl-11-methoxy-3a,5,7,11,13,15-pentamethyl-2,6,8,14-tetraoxo-1-(4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)butyl)tetradecahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazol-10-yl)oxy)-6-methyltetrahydro-2H-pyran-3-yl benzoate | C50H70N5O11 | 详情 | 详情 |
Extended Information