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【结 构 式】 
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【分子编号】66742 【品名】ethyl 1-(2-ethoxy-2-oxoethyl)piperidine-4-carboxylate 【CA登记号】1838-39-7 |
【 分 子 式 】C12H21NO4 【 分 子 量 】243.30308 【元素组成】C 59.24% H 8.7% N 5.76% O 26.3% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)
| 【1】 Daeniker HU, Grob CA. 1964. 3-Quinuclidone hydrochloride. Org Syn, 44: 86～90 |
| 【2】 Han XY, Liu H, Liu CH, et al. 2005. Synthesis of the optical rsomers of a new anticholinergic drug, penehyclidine hydrochloride (8018). Bioorg Med Chemm lett, 15(8):1979～1982 |
| 【3】 Ji JG, Li T. 2005. Preparatum of bicycloheterocyclyl substituted quiniculidine derivatives for use in pharmaceutical compositions which modulate the effects of α 7 nicotinic acetylcholine receptors(α 7 nAChR). US 2005137184 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43671 | ethyl isonicotinate | 1570-45-2 | C8H9NO2 | 详情 | 详情 |
| (II) | 66741 | 1-(2-ethoxy-2-oxoethyl)-4-(ethoxycarbonyl)pyridin-1-ium bromide | C12H16BrNO4 | 详情 | 详情 | |
| (III) | 66742 | ethyl 1-(2-ethoxy-2-oxoethyl)piperidine-4-carboxylate | 1838-39-7 | C12H21NO4 | 详情 | 详情 |
| (IV) | 66743 | ethyl 3-oxoquinuclidine-2-carboxylate | C10H15NO3 | 详情 | 详情 | |
| (V) | 66744 | quinuclidin-3-one hydrochloride | C7H11NO.HCl | 详情 | 详情 | |
| (VI) | 66745 | quinuclidin-3-ol | C7H13NO | 详情 | 详情 | |
| (VII) | 66746 | quinuclidin-3-yl acetate | C9H15NO2 | 详情 | 详情 | |
| (VIII) | 16152 | (3R)-1-azabicyclo[2.2.2]octan-3-ol; (R)-(-)-Quinuclidinol | 42437-96-7 | C7H13NO | 详情 | 详情 |
Extended Information