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【结 构 式】

【分子编号】66719

【品名】(R)-1-(benzyloxy)-4-(2,4,5-trifluorobenzyl)azetidin-2-one

【CA登记号】 

【 分 子 式 】C17H14F3NO2

【 分 子 量 】321.29891

【元素组成】C 63.55% H 4.39% F 17.74% N 4.36% O 9.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IX)

 

1 Hansen KB, Balsells J. Dreher S et a1. 2005. First Generation Process for the Preparation of the DPP-IV Inhibitor Sitagliptin. Org Proc Rea.Dev.,9(5): 634~639.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24075 2-chloropyrazine 14508-49-7 C4H3ClN2 详情 详情
(II) 66713 2-Hydrazinopyrazine 54608-52-5 C4H6N4 详情 详情
(III) 66714     C8H4F6N4O2 详情 详情
(IV) 66715 3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine   C6H3F3N4 详情 详情
(V) 66705 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 486460-21-3 C6H7F3N4.HCl 详情 详情
(VI) 66716 methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8 C11H9F3O3 详情 详情
(VII) 66717 (R)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid   C10H9F3O3 详情 详情
(VIII) 66718 (R)-N-(benzyloxy)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanamide   C17H16F3NO3 详情 详情
(IX) 66719 (R)-1-(benzyloxy)-4-(2,4,5-trifluorobenzyl)azetidin-2-one   C17H14F3NO2 详情 详情
(X) 66720 (R)-3-((benzyloxy)amino)-4-(2,4,5-trifluorophenyl)butanoic acid   C17H16F3NO3 详情 详情
(XI) 66721 (R)-3-((benzyloxy)amino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one   C23H21F6N5O2 详情 详情
(XII) 66722 (R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 486460-32-6 C16H15F6N5O 详情 详情
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