(E)-4-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)but-3-enoic acid -Drug Synthesis Database

【结构式】

【分子编号】66691

【品名】(E)-4-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)but-3-enoic acid

【CA登记号】　

【分子式】C₁₉H₂₂FN₃O₄S

【分子量】407.46590

【元素组成】C 56.01% H 5.44% F 4.66% N 10.31% O 15.71% S 7.87%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

【1】 Deshpande PB, Ramakrishnan A, Nilesh BS, et aL 2006. Process for preparation of calcium salt of rosuvastatin. W0 2006106526(本专利属于Unichem Laboratories Limited, India)
【2】 Deshpande PB, Ramakrishnan A, Nilesh BS, et al. 2006. Process for preparation of Rasuvastatin and its calcium salt. W0 2006100689(本专利属于Unichem Laboratories Limited, India)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23882	N-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide	147118-37-4	C₁₆H₁₈FN₃O₃S	详情	详情
(II)	66690	(E)-ethyl 4-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)but-3-enoate		C₂₁H₂₆FN₃O₄S	详情	详情
(III)	66691	(E)-4-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)but-3-enoic acid		C₁₉H₂₂FN₃O₄S	详情	详情
(IV)	66692	(E)-methyl 6-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-oxohex-5-enoate		C₂₂H₂₆FN₃O₅S	详情	详情
(V)	66693	(E)-methyl 6-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxyhex-5-enoate		C₂₂H₂₈FN₃O₅S	详情	详情
(VI)	66694	(E)-6-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxyhex-5-enoic acid		C₂₁H₂₆FN₃O₅S	详情	详情
(VII)	66695	(S,E)-6-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxyhex-5-enoic acid		C₂₁H₂₆FN₃O₅S	详情	详情
(VIII)	66696	(S,E)-methyl 8-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxy-3-oxooct-7-enoate		C₂₄H₃₀FN₃O₆S	详情	详情
(IX)	23885	methyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoate	147118-40-9	C₂₃H₃₀FN₃O₆S	详情	详情

Extended Information