(4-(2-(methylamino)ethoxy)phenyl)methanol -Drug Synthesis Database

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【结构式】

【分子编号】66657

【品名】(4-(2-(methylamino)ethoxy)phenyl)methanol

【CA登记号】　

【分子式】C₁₀H₁₅NO₂

【分子量】181.23464

【元素组成】C 66.27% H 8.34% N 7.73% O 17.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

合成路线1

该中间体在本合成路线中的序号： (V)

　

参考文献中间体

【1】 Giles RG. Lewis NJ, Quick JK, et aL. 2000. Regiospecific reduction of 5-benzylidene-2,4-thiuolidoines and 4-oxo-2-thiazolidinethiones using lithium borohydride in pyridine and tetrahydrofuran. Tetnhedron, 56: 4531～4537(本论文作者来自于SmithKline Beecham Pharmaceuticals．Old Powder Mills, Kent, UK)
【2】 Li X, Abell C, Warrington BH．et aL. 2003. Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia). Org Biomol Chem. 1: 4392～4395(本论文作者来自于Department of Chemistry, University Chemical Laboratories, Cambridge,UK)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(V)	66657	(4-(2-(methylamino)ethoxy)phenyl)methanol		C₁₀H₁₅NO₂	详情	详情
(I)	29474	4-(hydroxymethyl)phenol; 4-hydroxyphenylmethanol 4-hydroxybenzenemethanol; 4-Hydroxybenzyl alcohol	623-05-2	C₇H₈O₂	详情	详情
(II)	66655	ethyl 2-iodoacetate	623-48-3	C₄H₇IO₂	详情	详情
(III)	51988	ethyl 2-[4-(hydroxymethyl)phenoxy]acetate		C₁₁H₁₄O₄	详情	详情
(IV)	66656	2-(4-(hydroxymethyl)phenoxy)-N-methylacetamide		C₁₀H₁₃NO₃	详情	详情
(VI)	34512	2-fluoropyridine	372-48-5	C₅H₄FN	详情	详情
(VII)	66658	(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)methanol		C₁₅H₁₈N₂O₂	详情	详情
(VIII)	60164	4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzaldehyde		C₁₅H₁₆N₂O₂	详情	详情
(IX)	10883	1,3-Thiazolane-2,4-dione; 2,4-Thiazolidinedione	2295-31-0	C₃H₃NO₂S	详情	详情
(X)	59997			C₁₈H₁₇N₃O₃S	详情	详情

Extended Information