(R,E)-tert-butyl 2-((tert-butyldimethylsilyl)oxy)-6-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-4-oxohex-5-enoate -Drug Synthesis Database

【结构式】

【分子编号】66667

【品名】(R,E)-tert-butyl 2-((tert-butyldimethylsilyl)oxy)-6-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-4-oxohex-5-enoate

【CA登记号】　

【分子式】C₃₁H₄₆FN₃O₆SSi

【分子量】635.873

【元素组成】C 58.55% H 7.29% F 2.99% N 6.61% O 15.10% S 5.04% Si 4.42%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

参考文献中间体

合成目标

【1】 Balanov A, Shenkar N, Niddam-Hildeshehnv. 2007. Process for producing rousuvastatin. W0 2007041666(本专利属于Teva Pharmaceutical Industries Ltd．Isnel; Teva Pharmaceuticals USA, Inc)
【2】 Hiddam-Hijldesheim V, Balanov A, Shenkar N, et al. 2006. Preparation of rosuvastatin. W0 2006091771 (本专利属于Teva Pharmaceutial Industries Ltd，Israel; Teva Pharmaceuticals USA, Inc)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66663	(R)-1-tert-butyl 5-ethyl 3-((tert-butyldimethylsilyl)oxy)pentanedioate		C₁₇H₃₄O₅Si	详情	详情
(II)	66664	(R)-5-(tert-butoxy)-3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoic acid		C₁₅H₃₀O₅Si	详情	详情
(III)	66665	(S)-5-(tert-butoxy)-3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoic propionic anhydride		C₁₈H₃₄O₆Si	详情	详情
(IV)	66666	(R)-tert-butyl 3-((tert-butyldimethylsilyl)oxy)-6-(diethoxyphosphoryl)-5-oxohexanoate		C₂₀H₄₁O₇PSi	详情	详情
(V)	23882	N-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide	147118-37-4	C₁₆H₁₈FN₃O₃S	详情	详情
(VI)	66667	(R,E)-tert-butyl 2-((tert-butyldimethylsilyl)oxy)-6-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-4-oxohex-5-enoate		C₃₁H₄₆FN₃O₆SSi	详情	详情
(VII)	66662	(R,E)-tert-butyl 6-(4-(4-fluorophenyl)-6-isopropyl-2-(N- methylmethylsulfonamido)pyrimidin-5-yl)-2-hydroxy-4-oxohex-5-enoate		C₂₅H₃₂FN₃O₆S	详情	详情
(VIII)	66668	(2R,4S,E)-tert-butyl 6-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-2,4-dihydroxyhex-5-enoate		C₂₅H₃₄FN₃O₆S	详情	详情

Extended Information