(2S,3R)-5-(2-amino-6-(1H-imidazol-1-yl)-9H-purin-9-yl)-4-(hydroxymethyl)tetrahydrofuran-2,3-diol -Drug Synthesis Database

【结构式】

【分子编号】66541

【品名】(2S,3R)-5-(2-amino-6-(1H-imidazol-1-yl)-9H-purin-9-yl)-4-(hydroxymethyl)tetrahydrofuran-2,3-diol

【CA登记号】　

【分子式】C₁₃H₁₅N₇O₄

【分子量】333.307

【元素组成】C 46.85% H 4.54% N 29.42% O 19.20%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

【1】 Janeba Z,Lin XY, Robinsw.et aL 2004.FUnctionalization of guanosine and 2'-deoxyguanosine at C6:a modified appel process and SNAr displacement of imidazole. Nucl Acid, 23(1&2): 137～147
【2】 Nair V, Lyons AG. 1990. Hypoxanthine nucleoside counterparts of the antibiotic, cordycepin.Tetrahedron. 46 (23): 7677一7692

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66539	2-amino-9-((3aS,6S,6aS)-6-(hydroxymethyl)-2,2,3a,6a-tetramethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-3H-purin-6(9H)-one		C₁₅H₂₁N₅O₅	详情	详情
(II)	66540	9-((3aS,6S,6aS)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2,3a,6a-tetramethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(tritylamino)-3H-purin-6(9H)-one		C₄₀H₄₉N₅O₅Si	详情	详情
(III)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情
(IV)	66541	(2S,3R)-5-(2-amino-6-(1H-imidazol-1-yl)-9H-purin-9-yl)-4-(hydroxymethyl)tetrahydrofuran-2,3-diol		C₁₃H₁₅N₇O₄	详情	详情

Extended Information